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Heparin-induced thrombocytopenia and the use of r-hirudin during cardiopulmonary bypass
We report the successful use of r-hirudin (lepirudin) for cardiopulmonary bypass in a 67-year-old man who developed heparin-induced thrombocytopenia type II during heparin treatment of an extensive deep venous thrombosis. Lepirudin was monitored by the modified ecarin clotting time in a "mobile...
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| Published in: | Anaesthesia and intensive care 2005-06, Vol.33 (3), p.388-392 |
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| Main Authors: | , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c402t-1fc9f157d41a2b39d3c217d0a88bed4d1c648f5d557831b263a9b285d023e3433 |
| container_end_page | 392 |
| container_issue | 3 |
| container_start_page | 388 |
| container_title | Anaesthesia and intensive care |
| container_volume | 33 |
| creator | MANIKAPPA, S BENFIELD, K GAN, T. E BUTLER, J MALAN, E TRAN, H. A. M TUCKER, A |
| description | We report the successful use of r-hirudin (lepirudin) for cardiopulmonary bypass in a 67-year-old man who developed heparin-induced thrombocytopenia type II during heparin treatment of an extensive deep venous thrombosis. Lepirudin was monitored by the modified ecarin clotting time in a "mobile laboratory" set up next to the cardiac theatre, aiming for lepirudin levels of 3.5 to 4.5 microg/ml during bypass. |
| doi_str_mv | 10.1177/0310057x0503300316 |
| format | article |
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Cell therapy and gene therapy ; Biological and medical sciences ; Cardiopulmonary Bypass ; Heparin - adverse effects ; Hirudin Therapy ; Humans ; Male ; Medical sciences ; Monitoring, Intraoperative - methods ; Thrombocytopenia - chemically induced ; Thrombocytopenia - classification ; Venous Thrombosis - drug therapy</subject><ispartof>Anaesthesia and intensive care, 2005-06, Vol.33 (3), p.388-392</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Australian Society of Anaesthetists Jun 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-1fc9f157d41a2b39d3c217d0a88bed4d1c648f5d557831b263a9b285d023e3433</citedby><cites>FETCH-LOGICAL-c402t-1fc9f157d41a2b39d3c217d0a88bed4d1c648f5d557831b263a9b285d023e3433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16886493$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15973924$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MANIKAPPA, S</creatorcontrib><creatorcontrib>BENFIELD, K</creatorcontrib><creatorcontrib>GAN, T. 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| ispartof | Anaesthesia and intensive care, 2005-06, Vol.33 (3), p.388-392 |
| issn | 0310-057X 1448-0271 |
| language | eng |
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| source | Sage Journals Online; Alma/SFX Local Collection |
| subjects | Aged Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Cardiopulmonary Bypass Heparin - adverse effects Hirudin Therapy Humans Male Medical sciences Monitoring, Intraoperative - methods Thrombocytopenia - chemically induced Thrombocytopenia - classification Venous Thrombosis - drug therapy |
| title | Heparin-induced thrombocytopenia and the use of r-hirudin during cardiopulmonary bypass |
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