Development, Optimization, and Validation of Methods for Quantification of Veterinary Drug Residues in Complex Food Matrices Using Liquid-Chromatography—A Review

Developing a suitable method to detect the analytes of interest is of prime importance especially when it comes to multiclass methods. Which, in recent times, is gaining popularity due to its merits such as reduced time, reduced labor consumption, and lesser analytical runs. As the complexity of the...

Full description

Saved in:
Bibliographic Details
Published in:Food analytical methods 2019-08, Vol.12 (8), p.1823-1837
Main Authors: Manimekalai, M., Rawson, Ashish, Sengar, Animesh Singh, Kumar, K. Suresh
Format: Article
Language:English
Subjects:
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Chemometrics
Complexity
Drugs
Food
Food Science
Microbiology
Optimization
Reviews
Sample preparation
Selectivity
Sensitivity
Veterinary drug residues
Veterinary medicine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Developing a suitable method to detect the analytes of interest is of prime importance especially when it comes to multiclass methods. Which, in recent times, is gaining popularity due to its merits such as reduced time, reduced labor consumption, and lesser analytical runs. As the complexity of the matrix increases, selecting a suitable sample preparation technique becomes essential in order to increase the sensitivity and selectivity of the method. And finally, validation becomes a primary concern to determine whether the method developed is fit for its purpose. This review focuses on all these aspects with respect to the analysis of veterinary drugs present in food matrices. Furthermore, it also discusses recent trends in sample preparation techniques used specifically in animal-based/derived foods for the determination of veterinary drugs. Recent developments focusing on improving the sensitivity, recovery, and efficiency of the developed method through chemometrics has also been discussed in this review. Graphical abstract .
ISSN:1936-9751
1936-976X
DOI:10.1007/s12161-019-01512-9