Non‐natural Photoenzymatic Controlled Radical Polymerization Inspired by DNA Photolyase

Inspired by DNA photolyase, a non‐natural photoenzymatic catalysis of common flavoproteins is developed for controlled radical polymerization under irradiation of visible light. This photoenzymatic polymerization is highly efficient under mild conditions, applicable to various monomer families, suit...

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Bibliographic Details
Published in:Angewandte Chemie 2019-07, Vol.131 (28), p.9579-9584
Main Authors: Zhou, Fanfan, Li, Ruoyu, Wang, Xiao, Du, Simin, An, Zesheng
Format: Article
Language:English
Subjects:
Catalysis
Chemistry
Deoxygenation
Deoxyribonucleic acid
DNA
Enzyme
Flavoproteins
Irradiation
Kontrollierte radikalische Polymerisation
Photolyase
Photopolymerisation
Polymerization
Radiation
RAFT
Sichtbares Licht
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Summary:Inspired by DNA photolyase, a non‐natural photoenzymatic catalysis of common flavoproteins is developed for controlled radical polymerization under irradiation of visible light. This photoenzymatic polymerization is highly efficient under mild conditions, applicable to various monomer families, suitable for both homogeneous and heterogeneous media, and can be externally modulated by switching light on and off. A unique combination of the natural enzymatic deoxygenation with the non‐natural photoenzymatic process enables an unprecedented oxygen‐tolerant, visible‐light‐controlled radical polymerization using a single enzyme to be developed. Visible light activation of non‐natural catalytic functions of the widely distributed flavoproteins is an exciting conceptual advance and may uncover a hitherto underexplored field of photoenzymatic catalysis. Photoenzymatische Reaktionen sind in der Chemie selten. Inspiriert durch DNA‐Photolyase wurde eine nicht‐natürliche photoenzymatische kontrollierte radikalische Polymerisation für gewöhnliche Flavoproteine entwickelt.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201904413