Effect of dynamic and static loading during in vitro degradation of a braided composite bioresorbable cardiovascular stent

•Biomimetic loading affects the degradation of cardiovascular stents significantly.•Static compressive loading accelerated the hydrolysis process.•Dynamic loading attenuated the degradation rate and the autocatalysis process. Bioresorbable cardiovascular stents are usually subjected to dynamic mecha...

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Bibliographic Details
Published in:Materials letters 2019-09, Vol.250, p.12-15
Main Authors: Zhao, Fan, Wang, Fujun, King, Martin W., Wang, Lu
Format: Article
Language:English
Subjects:
Autocatalysis
Biocompatibility
Biomedical materials
Biomimetic
Braided composites
Braiding
Degradation
Dynamic loads
Dynamic tests
Fibre technology
Immersion tests (corrosion)
In vitro methods and tests
In vivo methods and tests
Materials science
Polymeric composites
Stents
Struts
Surgical implants
Viscous flow
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Summary:•Biomimetic loading affects the degradation of cardiovascular stents significantly.•Static compressive loading accelerated the hydrolysis process.•Dynamic loading attenuated the degradation rate and the autocatalysis process. Bioresorbable cardiovascular stents are usually subjected to dynamic mechanical loads in vivo, which results in a different degradation profile compared to that measured under a static in vitro immersion test. In this study, a dynamic test platform was used to mimic cyclic pulsatile pressure and compared the changes in polymer properties of poly(p-dioxaone)/polycaprolane (PPDO/PCL) braided composite bioresorbable stents (BCBRSs) with static loading and non-loaded environments. The results showed static compressive load accelerated the changes in the hydrolysis process and crystallinity for polymers while the pulsatile pressure increased surface corrosion of the stent struts. Moreover, the degradation rate under dynamic loading was attenuated due to the mitigation of viscous flow of molecule chains and autocatalysis process, compared with that under static loading and non-loaded conditions.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2019.04.097