Direct visualization of drug release in injectable implant by laser induced breakdown spectroscopy (LIBS)

Understanding the drug release mechanisms of long-acting injectable (LAI) formulations is of great interest to the pharmaceutical community, yet remains a complex analytical challenge. Herein, the drug release process of LAI implants were directly visualized for the first time using laser induced br...

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Bibliographic Details
Published in:Journal of analytical atomic spectrometry 2019-07, Vol.34 (7), p.1351-1354
Main Authors: Zou, Lanfang, Stenslik, Mallory J, Giles, Morgan B, Ormes, James D, Marsales, Maureen, Santos, Carlos, Kassim, Brittany, Smith, Joseph P, Gonzalez, Jhanis J, Bu, Xiaodong
Format: Article
Language:English
Subjects:
Drug delivery systems
Fluorine
Formulations
Implants
In vitro methods and tests
Laser induced breakdown spectroscopy
Mapping
Pharmaceuticals
Spectroscopy
Spectrum analysis
Transplants & implants
Visualization
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Summary:Understanding the drug release mechanisms of long-acting injectable (LAI) formulations is of great interest to the pharmaceutical community, yet remains a complex analytical challenge. Herein, the drug release process of LAI implants were directly visualized for the first time using laser induced breakdown spectroscopy (LIBS) 2D imaging. To directly visualize the active pharmaceutical ingredient (API) at different stages of in vitro drug release, the 685.60 nm fluorine atomic emission line was used to quantify the amount of API. Results indicate that at all time points examined, LIBS and traditional in vitro testing by UPLC were highly correlative, therefore supporting the potential application of LIBS for rapid visualization and direct quantitative mapping of drug in a LAI implant. A novel laser induced breakdown spectroscopy (LIBS) 2D imaging method is used to directly visualize the drug release process of long-acting injectable (LAI) implants for the first time.
ISSN:0267-9477
1364-5544
DOI:10.1039/c9ja00104b