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New variant of acute promyelocytic leukemia with IRF 2 BP 2– RARA fusion

We present an acute promyelocytic leukemia ( APL ) patient with two subtypes of IRF 2 BP 2– RARA , in which the IRF 2 BP 2 gene showed completely new breakpoints. Bone marrow examination revealed morphologic features indicative of APL . However, promyelocytic leukemia – RARA fusion was not detected....

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Bibliographic Details
Published in:Cancer science 2016-08, Vol.107 (8), p.1165-1168
Main Authors: Shimomura, Yoshimitsu, Mitsui, Hideki, Yamashita, Yukiko, Kamae, Tsuyoshi, Kanai, Akinori, Matsui, Hirotaka, Ishibashi, Tomohiko, Tanimura, Akira, Shibayama, Hirohiko, Oritani, Kenji, Kuyama, Jun, Kanakura, Yuzuru
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Language:English
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Summary:We present an acute promyelocytic leukemia ( APL ) patient with two subtypes of IRF 2 BP 2– RARA , in which the IRF 2 BP 2 gene showed completely new breakpoints. Bone marrow examination revealed morphologic features indicative of APL . However, promyelocytic leukemia – RARA fusion was not detected. A paired‐end mRNA sequencing followed by RT ‐ PCR and direct sequencing revealed two types of fusion transcripts between exon 1B of IRF 2 BP 2 and exon 3 of RARA . The patient received all‐trans retinoic acid and conventional chemotherapy, but showed resistance. This is the second report of IRF 2 BP 2 involvement in APL , and we describe various breakpoints for the IRF 2 BP 2– RARA fusion gene.
ISSN:1347-9032
1349-7006
DOI:10.1111/cas.12970