Influence of peroxisome proliferator-activated receptor ³ activation by its endogenous ligand 15-deoxy "12,14 prostaglandin J2 on nitric oxide production in term placental tissues from diabetic women

• Published in: Molecular human reproduction 2004-09, Vol.10 (9), p.671
• Main Authors: Jawerbaum, A, Capobianco, E, Pustovrh, C, White, V, Baier, M, Salzberg, S, Pesaresi, M, Gonzalez, E
• Format: Article
• Language: English
• ISSN: 1360-9947; 1460-2407

Diabetes induces alterations which condition placental remodelling. The levels of nitric oxide (NO) (a modulator of placental invasiveness, differentiation and proliferation) were higher in term placental explants from diabetic patients when compared to controls. Peroxisome proliferator-activated receptor gamma (PPARgamma) activation by its endogenous ligand 15-deoxy Delta(12,14)prostaglandin J(2) (15dPGJ(2)), is a differentiating factor of adipocytes and other cell types, such as trophoblasts. 15dPGJ(2) is also able to down-regulate NO production in different cell types. Our study evaluated the levels of 15dPGJ(2) and PPARgamma and the influence of PPARgamma activation by 15dPGJ(2) on the production of NO, in term placental tissues from control, pre-gestational and gestational diabetic patients. Our results showed that 15dPGJ(2) was present in human term placenta, and that its levels were diminished in gestational (P