Sodium Alginate Based Mucoadhesive Hydrogels

The potential use of sodium-alginate hydrogels as mucoadhesive drug delivery carriers for intranasal application is studied. It is demonstrated that the drug release rate is dependent on the drug solubility in water, the drug concentration in the carrier, and the degree of alginate crosslinking.

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Bibliographic Details
Published in:Applied biochemistry and microbiology 2019-07, Vol.55 (4), p.371-374
Main Authors: Gorshkova, M. Yu, Volkova, I. F., Vanchugova, L. V., Valuev, I. L., Valuev, L. I.
Format: Article
Language:English
Subjects:
Alginic acid
Biochemistry
Biomedical and Life Sciences
Carrier density
Crosslinking
Drug delivery
Drug delivery systems
Hydrogels
Life Sciences
Medical Microbiology
Microbiology
Sodium
Sodium alginate
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Description
Summary:The potential use of sodium-alginate hydrogels as mucoadhesive drug delivery carriers for intranasal application is studied. It is demonstrated that the drug release rate is dependent on the drug solubility in water, the drug concentration in the carrier, and the degree of alginate crosslinking.
ISSN:0003-6838
1608-3024
DOI:10.1134/S0003683819040045