VITAMIN D AS AN ADJUVANT THERAPY TO CURE ORAL LICHEN PLANUS IN PERI-MENOPAUSAL WOMEN

The purpose of this study is to investigate Vitamin D supplementation as an adjunctive method in curing the progression of lichen planus among peri-menopausal women. A randomized clinical trial was performed on peri-menopausal women falling in Department of Oral Medicine and Diagnosis, Ziauddin Univ...

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Bibliographic Details
Published in:Pakistan oral & dental journal 2018-12, Vol.38 (4), p.399
Main Authors: Razi, Afifa, Mohiuddin, Sidra, ATIYA ABDUL KARIM, Iqbal, Atif
Format: Article
Language:English
Subjects:
Adjuvant therapy
Analysis
Autoimmune diseases
Care and treatment
Clinical trials
Dietary supplements
Disease
Health aspects
Hormone replacement therapy
Investigations
Lichen planus
Menopause
Oral diseases
Pain
Prevalence studies (Epidemiology)
Signs and symptoms
Skin
Vitamin D
Vitamin D deficiency
Vitamin deficiency
Vitamins
Women
Womens health
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Summary:The purpose of this study is to investigate Vitamin D supplementation as an adjunctive method in curing the progression of lichen planus among peri-menopausal women. A randomized clinical trial was performed on peri-menopausal women falling in Department of Oral Medicine and Diagnosis, Ziauddin University from January 2018-September 2018. Diagnosed clinically with sub-type of Oral Lichen Planus and serum 25(OH) Vitamin D levels below30ng/ml and aged bracket between 35-45 years were included. A flip coin method was used to allocate study participants in two groups: one group receiving conventional therapy and other group supplemented with vitamin D and conventional therapy altogether. Pain intensity assessed on Visual analogue scale and lesion characteristics assessed as sub-site score were recorded for all study participants at baseline, week 1 and week 4 of follow up. Paired-sample t-test was applied to measure difference in pain intensity and sub site scores at week 1 and week 4 of the therapy. The level of significance was considered to be less than 0.05. Pain scores were recorded between week 1 and week 4 for standard therapy with a pain intensity score of 5.04±2.20 and 1.80±0.40, p value less than 0.001. Subjects in group 2 shows improvement in clinical appearance of lesion between week 1 (1.80±0.40) and week 4 (0.80±0.40), p-value less than 0.001. Vitamin D deficiency is mostly common in peri menopausal women and is associated with Oral Lichen Planus cases, thus showing its relationship.
ISSN:1012-8700
1996-4439