Developmental toxicity of the angiotensin II type 1 receptor antagonists during human pregnancy: a report of 10 cases

Objective  Angiotensin II type 1 receptor antagonists (ARA). Interacted with the renin–angiotensin system, and the present study was undertaken to examine their fetal and neonatal toxicity when taken by the mother during pregnancy. Design  Prospective follow up of pregnant women exposed to an ARA du...

Full description

Saved in:
Bibliographic Details
Published in:BJOG : an international journal of obstetrics and gynaecology 2005-06, Vol.112 (6), p.710-712
Main Authors: Serreau, Raphael, Luton, Dominique, Macher, Marie‐Alice, Delezoide, Anne‐Lise, Garel, Catherine, Jacqz‐Aigrain, Evelyne
Format: Article
Language:English
Subjects:
Abnormalities, Drug-Induced - diagnostic imaging
Abnormalities, Drug-Induced - etiology
Adult
Angiotensin II Type 1 Receptor Blockers
Antihypertensive Agents
Biological and medical sciences
Contraindications
Female
Fetus - abnormalities
Follow-Up Studies
Gynecology. Andrology. Obstetrics
Humans
Hypertension, Pregnancy-Induced - drug therapy
Medical sciences
Obstetrics
Pregnancy
Prospective Studies
Proteins
Renin-Angiotensin System - drug effects
Teratogens - toxicity
Toxicity
Ultrasonography, Prenatal
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective  Angiotensin II type 1 receptor antagonists (ARA). Interacted with the renin–angiotensin system, and the present study was undertaken to examine their fetal and neonatal toxicity when taken by the mother during pregnancy. Design  Prospective follow up of pregnant women exposed to an ARA during early pregnancy. Setting  The present study was conducted in the departments of Paedriatric Pharmacology of the University hospital Robert Debré in Paris, France. Population  Ten women exposed to an ARA during early pregnancy. Methods  Prospective follow up. Main outcome measure  Fetal ultrasonography and outcome of pregnancy. Results  Prenatal ultrasonography showed abnormal features in five cases (oligoamnios related to fetal tabular dysgenesis, fetal dysmorphia and renal abnormalities). Outcome of pregnancy was as follows: three induced abortions, two stillbirths (twin pregnancy), one neonate presenting with dysmorphia and renal disease and five neonates with an uneventful development. Conclusion  Women of reproductive age should be advised of the possible hazards of ARA and treatment should be stopped as soon as pregnany has been documented.
ISSN:1470-0328
1471-0528
DOI:10.1111/j.1471-0528.2004.00525.x