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Developmental toxicity of the angiotensin II type 1 receptor antagonists during human pregnancy: a report of 10 cases
Objective Angiotensin II type 1 receptor antagonists (ARA). Interacted with the renin–angiotensin system, and the present study was undertaken to examine their fetal and neonatal toxicity when taken by the mother during pregnancy. Design Prospective follow up of pregnant women exposed to an ARA du...
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| Published in: | BJOG : an international journal of obstetrics and gynaecology 2005-06, Vol.112 (6), p.710-712 |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c4255-4198d856be47956a42afa039ae6e0ac6da5ecec2d01d270f3a03cc4060bee85b3 |
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| cites | cdi_FETCH-LOGICAL-c4255-4198d856be47956a42afa039ae6e0ac6da5ecec2d01d270f3a03cc4060bee85b3 |
| container_end_page | 712 |
| container_issue | 6 |
| container_start_page | 710 |
| container_title | BJOG : an international journal of obstetrics and gynaecology |
| container_volume | 112 |
| creator | Serreau, Raphael Luton, Dominique Macher, Marie‐Alice Delezoide, Anne‐Lise Garel, Catherine Jacqz‐Aigrain, Evelyne |
| description | Objective Angiotensin II type 1 receptor antagonists (ARA). Interacted with the renin–angiotensin system, and the present study was undertaken to examine their fetal and neonatal toxicity when taken by the mother during pregnancy.
Design Prospective follow up of pregnant women exposed to an ARA during early pregnancy.
Setting The present study was conducted in the departments of Paedriatric Pharmacology of the University hospital Robert Debré in Paris, France.
Population Ten women exposed to an ARA during early pregnancy.
Methods Prospective follow up.
Main outcome measure Fetal ultrasonography and outcome of pregnancy.
Results Prenatal ultrasonography showed abnormal features in five cases (oligoamnios related to fetal tabular dysgenesis, fetal dysmorphia and renal abnormalities). Outcome of pregnancy was as follows: three induced abortions, two stillbirths (twin pregnancy), one neonate presenting with dysmorphia and renal disease and five neonates with an uneventful development.
Conclusion Women of reproductive age should be advised of the possible hazards of ARA and treatment should be stopped as soon as pregnany has been documented. |
| doi_str_mv | 10.1111/j.1471-0528.2004.00525.x |
| format | article |
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Design Prospective follow up of pregnant women exposed to an ARA during early pregnancy.
Setting The present study was conducted in the departments of Paedriatric Pharmacology of the University hospital Robert Debré in Paris, France.
Population Ten women exposed to an ARA during early pregnancy.
Methods Prospective follow up.
Main outcome measure Fetal ultrasonography and outcome of pregnancy.
Results Prenatal ultrasonography showed abnormal features in five cases (oligoamnios related to fetal tabular dysgenesis, fetal dysmorphia and renal abnormalities). Outcome of pregnancy was as follows: three induced abortions, two stillbirths (twin pregnancy), one neonate presenting with dysmorphia and renal disease and five neonates with an uneventful development.
Conclusion Women of reproductive age should be advised of the possible hazards of ARA and treatment should be stopped as soon as pregnany has been documented.</description><identifier>ISSN: 1470-0328</identifier><identifier>EISSN: 1471-0528</identifier><identifier>DOI: 10.1111/j.1471-0528.2004.00525.x</identifier><identifier>PMID: 15924524</identifier><identifier>CODEN: BIOGFQ</identifier><language>eng</language><publisher>Oxford, UK and Malden, USA: Blackwell Science Ltd</publisher><subject>Abnormalities, Drug-Induced - diagnostic imaging ; Abnormalities, Drug-Induced - etiology ; Adult ; Angiotensin II Type 1 Receptor Blockers ; Antihypertensive Agents ; Biological and medical sciences ; Contraindications ; Female ; Fetus - abnormalities ; Follow-Up Studies ; Gynecology. Andrology. Obstetrics ; Humans ; Hypertension, Pregnancy-Induced - drug therapy ; Medical sciences ; Obstetrics ; Pregnancy ; Prospective Studies ; Proteins ; Renin-Angiotensin System - drug effects ; Teratogens - toxicity ; Toxicity ; Ultrasonography, Prenatal</subject><ispartof>BJOG : an international journal of obstetrics and gynaecology, 2005-06, Vol.112 (6), p.710-712</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Elsevier Science Ltd. Jun 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4255-4198d856be47956a42afa039ae6e0ac6da5ecec2d01d270f3a03cc4060bee85b3</citedby><cites>FETCH-LOGICAL-c4255-4198d856be47956a42afa039ae6e0ac6da5ecec2d01d270f3a03cc4060bee85b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16815687$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15924524$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Serreau, Raphael</creatorcontrib><creatorcontrib>Luton, Dominique</creatorcontrib><creatorcontrib>Macher, Marie‐Alice</creatorcontrib><creatorcontrib>Delezoide, Anne‐Lise</creatorcontrib><creatorcontrib>Garel, Catherine</creatorcontrib><creatorcontrib>Jacqz‐Aigrain, Evelyne</creatorcontrib><title>Developmental toxicity of the angiotensin II type 1 receptor antagonists during human pregnancy: a report of 10 cases</title><title>BJOG : an international journal of obstetrics and gynaecology</title><addtitle>BJOG</addtitle><description>Objective Angiotensin II type 1 receptor antagonists (ARA). Interacted with the renin–angiotensin system, and the present study was undertaken to examine their fetal and neonatal toxicity when taken by the mother during pregnancy.
Design Prospective follow up of pregnant women exposed to an ARA during early pregnancy.
Setting The present study was conducted in the departments of Paedriatric Pharmacology of the University hospital Robert Debré in Paris, France.
Population Ten women exposed to an ARA during early pregnancy.
Methods Prospective follow up.
Main outcome measure Fetal ultrasonography and outcome of pregnancy.
Results Prenatal ultrasonography showed abnormal features in five cases (oligoamnios related to fetal tabular dysgenesis, fetal dysmorphia and renal abnormalities). Outcome of pregnancy was as follows: three induced abortions, two stillbirths (twin pregnancy), one neonate presenting with dysmorphia and renal disease and five neonates with an uneventful development.
Conclusion Women of reproductive age should be advised of the possible hazards of ARA and treatment should be stopped as soon as pregnany has been documented.</description><subject>Abnormalities, Drug-Induced - diagnostic imaging</subject><subject>Abnormalities, Drug-Induced - etiology</subject><subject>Adult</subject><subject>Angiotensin II Type 1 Receptor Blockers</subject><subject>Antihypertensive Agents</subject><subject>Biological and medical sciences</subject><subject>Contraindications</subject><subject>Female</subject><subject>Fetus - abnormalities</subject><subject>Follow-Up Studies</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Hypertension, Pregnancy-Induced - drug therapy</subject><subject>Medical sciences</subject><subject>Obstetrics</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><subject>Proteins</subject><subject>Renin-Angiotensin System - drug effects</subject><subject>Teratogens - toxicity</subject><subject>Toxicity</subject><subject>Ultrasonography, Prenatal</subject><issn>1470-0328</issn><issn>1471-0528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqNkEuP0zAURi0EYh7wF5CFxDLh2rFThwUSMwxQNNJsYG25zk0nVWoH24Hm3-O0FbPFG1_pO_ehQwhlULL83u9KJlasAMlVyQFECbmU5eEZufwXPD_WUEDF1QW5inEHwGoO1UtywWTDheTikkyf8TcOftyjS2agyR9626eZ-o6mR6TGbXuf0MXe0fWapnlEymhAi2PyIcfJbL3rY4q0nULvtvRx2htHx4BbZ5ydP1CT8dGHtIxkQK2JGF-RF50ZIr4-_9fk55e7H7ffivuHr-vbT_eFFVzKQrBGtUrWGxSrRtZGcNMZqBqDNYKxdWtkvsTyFljLV9BVObRWQA0bRCU31TV5e5o7Bv9rwpj0zk_B5ZWa5wWKQyMypE6QDT7GgJ0eQ783YdYM9KJb7_RiVS9W9aJbH3XrQ259c54_bfbYPjWe_Wbg3Rkw0ZqhC9lJH5-4WjFZq1XmPp64P_2A838foG--PxzL6i-l0JwD</recordid><startdate>200506</startdate><enddate>200506</enddate><creator>Serreau, Raphael</creator><creator>Luton, Dominique</creator><creator>Macher, Marie‐Alice</creator><creator>Delezoide, Anne‐Lise</creator><creator>Garel, Catherine</creator><creator>Jacqz‐Aigrain, Evelyne</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>K9.</scope></search><sort><creationdate>200506</creationdate><title>Developmental toxicity of the angiotensin II type 1 receptor antagonists during human pregnancy: a report of 10 cases</title><author>Serreau, Raphael ; Luton, Dominique ; Macher, Marie‐Alice ; Delezoide, Anne‐Lise ; Garel, Catherine ; Jacqz‐Aigrain, Evelyne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4255-4198d856be47956a42afa039ae6e0ac6da5ecec2d01d270f3a03cc4060bee85b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Abnormalities, Drug-Induced - diagnostic imaging</topic><topic>Abnormalities, Drug-Induced - etiology</topic><topic>Adult</topic><topic>Angiotensin II Type 1 Receptor Blockers</topic><topic>Antihypertensive Agents</topic><topic>Biological and medical sciences</topic><topic>Contraindications</topic><topic>Female</topic><topic>Fetus - abnormalities</topic><topic>Follow-Up Studies</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Hypertension, Pregnancy-Induced - drug therapy</topic><topic>Medical sciences</topic><topic>Obstetrics</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><topic>Proteins</topic><topic>Renin-Angiotensin System - drug effects</topic><topic>Teratogens - toxicity</topic><topic>Toxicity</topic><topic>Ultrasonography, Prenatal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Serreau, Raphael</creatorcontrib><creatorcontrib>Luton, Dominique</creatorcontrib><creatorcontrib>Macher, Marie‐Alice</creatorcontrib><creatorcontrib>Delezoide, Anne‐Lise</creatorcontrib><creatorcontrib>Garel, Catherine</creatorcontrib><creatorcontrib>Jacqz‐Aigrain, Evelyne</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Serreau, Raphael</au><au>Luton, Dominique</au><au>Macher, Marie‐Alice</au><au>Delezoide, Anne‐Lise</au><au>Garel, Catherine</au><au>Jacqz‐Aigrain, Evelyne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Developmental toxicity of the angiotensin II type 1 receptor antagonists during human pregnancy: a report of 10 cases</atitle><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle><addtitle>BJOG</addtitle><date>2005-06</date><risdate>2005</risdate><volume>112</volume><issue>6</issue><spage>710</spage><epage>712</epage><pages>710-712</pages><issn>1470-0328</issn><eissn>1471-0528</eissn><coden>BIOGFQ</coden><abstract>Objective Angiotensin II type 1 receptor antagonists (ARA). Interacted with the renin–angiotensin system, and the present study was undertaken to examine their fetal and neonatal toxicity when taken by the mother during pregnancy.
Design Prospective follow up of pregnant women exposed to an ARA during early pregnancy.
Setting The present study was conducted in the departments of Paedriatric Pharmacology of the University hospital Robert Debré in Paris, France.
Population Ten women exposed to an ARA during early pregnancy.
Methods Prospective follow up.
Main outcome measure Fetal ultrasonography and outcome of pregnancy.
Results Prenatal ultrasonography showed abnormal features in five cases (oligoamnios related to fetal tabular dysgenesis, fetal dysmorphia and renal abnormalities). Outcome of pregnancy was as follows: three induced abortions, two stillbirths (twin pregnancy), one neonate presenting with dysmorphia and renal disease and five neonates with an uneventful development.
Conclusion Women of reproductive age should be advised of the possible hazards of ARA and treatment should be stopped as soon as pregnany has been documented.</abstract><cop>Oxford, UK and Malden, USA</cop><pub>Blackwell Science Ltd</pub><pmid>15924524</pmid><doi>10.1111/j.1471-0528.2004.00525.x</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 1470-0328 |
| ispartof | BJOG : an international journal of obstetrics and gynaecology, 2005-06, Vol.112 (6), p.710-712 |
| issn | 1470-0328 1471-0528 |
| language | eng |
| recordid | cdi_proquest_journals_225582094 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Abnormalities, Drug-Induced - diagnostic imaging Abnormalities, Drug-Induced - etiology Adult Angiotensin II Type 1 Receptor Blockers Antihypertensive Agents Biological and medical sciences Contraindications Female Fetus - abnormalities Follow-Up Studies Gynecology. Andrology. Obstetrics Humans Hypertension, Pregnancy-Induced - drug therapy Medical sciences Obstetrics Pregnancy Prospective Studies Proteins Renin-Angiotensin System - drug effects Teratogens - toxicity Toxicity Ultrasonography, Prenatal |
| title | Developmental toxicity of the angiotensin II type 1 receptor antagonists during human pregnancy: a report of 10 cases |
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