Efficient Three-Component One-Pot Synthesis of 4H-Pyrans

Clean, practical, and efficient electrochemical synthesis of pharmaceutically relevant 4 H -pyran derivatives by one-pot three-component combination of an aryl aldehyde, malononitrile, and a dicarbonyl compoundis developed. The synthesis is performed in ethanol with lithium perchlorate as a supporti...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2019-05, Vol.55 (5), p.686-693
Main Authors: Malviya, J., Kala, S., Sharma, L. K., Singh, R. K. P.
Format: Article
Language:English
Subjects:
Aldehydes
Aromatic compounds
Chemical synthesis
Chemistry
Chemistry and Materials Science
Electrolysis
Ethanol
Lithium
Malononitrile
Organic Chemistry
Platinum
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Summary:Clean, practical, and efficient electrochemical synthesis of pharmaceutically relevant 4 H -pyran derivatives by one-pot three-component combination of an aryl aldehyde, malononitrile, and a dicarbonyl compoundis developed. The synthesis is performed in ethanol with lithium perchlorate as a supporting electrolyte in an undivided cell on a platinum electrode under constant potential electrolysis conditions.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428019050178