Impact of permeabilization and pH effects in the electrochemical treatment of tumors: Experiments and simulations

•Electrolysis products have a major role in electrochemical treatment of Tumors(EChT).•This work evidences that the extreme pH fronts affect the permeabilization of the tissue and consequently its destruction.•Modeled ions demonstrate the diffusive regime of ionic transport and show the low influenc...

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Bibliographic Details
Published in:Applied Mathematical Modelling 2019-10, Vol.74, p.62-72
Main Authors: Calzado, E.M., Schinca, H., Cabrales, L.E.B., García, F.M., Turjanski, P., Olaiz, N.
Format: Article
Language:English
Subjects:
Computer simulation
Electric fields
Electrochemical treatment
Electrodes
Organic chemistry
Permeabilization factor
PH fronts
Potato (solanum tuberosum l.)
Potatoes
Tissue damage
Transport
Tumor
Tumors
Two dimensional models
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Summary:•Electrolysis products have a major role in electrochemical treatment of Tumors(EChT).•This work evidences that the extreme pH fronts affect the permeabilization of the tissue and consequently its destruction.•Modeled ions demonstrate the diffusive regime of ionic transport and show the low influence of the electric field on EChT. Electrochemical treatment is used in the local control of solid tumors in preclinical and clinical studies. We study pH fronts, permeabilization, electrical field and concentration of four chemical species in a tissue under electrochemical treatment by means of in vitro and in silico modeling. The in vitro model uses a piece of potato (solanum tuberosum L.) as analogy of tumor tissue, due to the characteristics of the potato tissue and the way in which it reacts against pH and potential. The in silico model solves the two-dimensional Nernst-Planck equations for ionic transport in a four-ion electrolyte. Modeled ions demonstrate the diffusive regime of ionic transport and show the little influence of the low electric field applied on this phenomenon. This work evidences that extreme pH fronts affect the permeabilization of the tissue and consequently its destruction. We also evaluate different shapes of electrode arrays by means of simulated and in vitro models. We concluded that the higher area of necrotic tissue was achieved for the greater separation between electrodes.
ISSN:0307-904X
1088-8691
0307-904X
DOI:10.1016/j.apm.2019.04.041