Hepatitis B and/or C co-infection in HIV infected patients: A study in a tertiary care centre from south India

Background & objectives: Co-infection with hepatitis B virus (HBV) and hepatitis C virus (HCV) in human immunodeficiency virus (HIV) infected individuals results in increased hepatic complications. We undertook this study to evaluate the presence of HBV and HCV in HIV infected individuals attend...

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Bibliographic Details
Published in:Indian journal of medical research (New Delhi, India : 1994) India : 1994), 2013-12, Vol.137 (6), p.950-954
Main Authors: Chandra, Naval, Joshi, Nayana, Y.S.N Raju, Kumar, Ajit, Teja, Vijay
Format: Article
Language:English
Subjects:
Antigens
Blood transfusions
Disease transmission
Drug abuse
Gastroenterology
Hepatitis
Hepatitis B
HIV
Human immunodeficiency virus
Immunoglobulins
Infections
Liver diseases
Patients
Statistical analysis
Variables
Variance analysis
Viral infections
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Summary:Background & objectives: Co-infection with hepatitis B virus (HBV) and hepatitis C virus (HCV) in human immunodeficiency virus (HIV) infected individuals results in increased hepatic complications. We undertook this study to evaluate the presence of HBV and HCV in HIV infected individuals attending a tertiary care centre in southern India. Methods: A total of 120 cases with HIV infection and 120 healthy adult control subjects were included in the study. Samples were tested for hepatitis B surface antigen (HBsAg) and anti-HCV antibodies by enzyme linked immunosorbent assay (ELISA) method. HBsAg and anti-HCV positive serum samples were further tested for the presence of hepatitis B e antigen (HBeAg), anti-HBe antibodies, HBV-DNA and HCV-RNA. Results: The most common mode of transmission was sexual promiscuity (79%), followed by spouse positivity (15%) and history of blood transfusion (6%). HBsAg and anti-HCV were positive in 18 (15%) and 10 (8.3%) HIV infected patients; the corresponding figures in healthy controls being 2 (1.6%) 0 (0%) (P
ISSN:0971-5916