Fasudil alleviates brain damage in rats after carbon monoxide poisoning through regulating neurite outgrowth inhibitor/oligodendrocytemyelin glycoprotein signalling pathway

Carbon monoxide (CO) poisoning can lead to many serious neurological symptoms. Currently, there are no effective therapies for CO poisoning. In this study, rats exposed to CO received hyperbaric oxygen therapy, and those in the Fasudil group were given additional Fasudil injection once daily. We fou...

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Bibliographic Details
Published in:Basic & clinical pharmacology & toxicology 2019-08, Vol.125 (2), p.152-165
Main Authors: Wang, Li, Xu, Jianghua, Guo, Dadong, Zhou, Xudong, Jiang, Wenwen, Wang, Jinglin, Tang, Jiyou, Zou, Yong, Bi, Mingjun, Li, Qin
Format: Article
Language:English
Subjects:
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - therapeutic use
Animals
Axonogenesis
Brain
Brain - drug effects
Brain - pathology
Brain damage
Brain injury
Carbon monoxide
Carbon Monoxide - toxicity
Carbon monoxide poisoning
Carbon Monoxide Poisoning - drug therapy
Carbon Monoxide Poisoning - etiology
Carbon Monoxide Poisoning - pathology
CO poisoning
cognitive function
Disease Models, Animal
Drug Evaluation, Preclinical
Fasudil
Glycoproteins
GPI-Linked Proteins - metabolism
Head injuries
Humans
Hyperbaric oxygen therapy
Inhalation
Inhibitors
Latency
Male
Mitochondria
Myelin
Myelin Proteins - metabolism
Nogo
Nogo protein
Nogo Proteins - metabolism
Oligodendrocyte-myelin glycoprotein
OMgp
Poisoning
Protein Kinase Inhibitors - pharmacology
Protein Kinase Inhibitors - therapeutic use
Proteins
Rats
rho-Associated Kinases - antagonists & inhibitors
rho-Associated Kinases - metabolism
Rock
Rocks
Signal transduction
Signal Transduction - drug effects
Signaling
Signs and symptoms
Structure-function relationships
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Description
Summary:Carbon monoxide (CO) poisoning can lead to many serious neurological symptoms. Currently, there are no effective therapies for CO poisoning. In this study, rats exposed to CO received hyperbaric oxygen therapy, and those in the Fasudil group were given additional Fasudil injection once daily. We found that the escape latency in CO poisoning group (CO group) was significantly prolonged, the T1/Ttotal was obviously decreased, and the mean escape time and the active escape latency were notably extended compared with those in normal control group (NC group, P 1 week, P 
ISSN:1742-7835
1742-7843
DOI:10.1111/bcpt.13233