Efficient synthesis and anti-bovine viral diarrhea virus evaluation of 5-(aryldiazo)salicylaldehyde thiosemicarbazone derivatives

An efficient procedure for the synthesis of 5-(aryldiazo)salicylaldehyde thiosemicarbazone derivatives 1-25 was achieved via the condensation of 5-(aryldiazo)salicylaldehyde derivatives I-V with N-(4)-substituted thiosemicarbazide derivatives. Antiviral activity of the synthesized compounds was carr...

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Bibliographic Details
Published in:Synthetic communications 2019-09, Vol.49 (18), p.2411-2416
Main Authors: Abbas, Samir Y., Basyouni, Wahid M., El-Bayouki, Khairy A. M., Dawood, Reham M., Abdelhafez, Tawfeek H., Elawady, Mostafa K.
Format: Article
Language:English
Subjects:
anti-bovine viral diarrhea virus
Derivatives
N > substituted thiosemicarbazides
Salicylaldehydes
Synthesis
thiosemicarbazones
Viruses
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Summary:An efficient procedure for the synthesis of 5-(aryldiazo)salicylaldehyde thiosemicarbazone derivatives 1-25 was achieved via the condensation of 5-(aryldiazo)salicylaldehyde derivatives I-V with N-(4)-substituted thiosemicarbazide derivatives. Antiviral activity of the synthesized compounds was carried out. From the obtained results, it was noticed that compound 11 has a strong antiviral activity.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2019.1626893