β-Cyclodextrin as a Biomimetic Catalyst for the Efficient Synthesis of 4-Oxo-pyrido[1,2-a] Pyrimidine-3-Carbonitrile in Aqueous Medium

Supramolecular β-cyclodextrin as a highly efficient, biodegradable, and reusable catalyst for the synthesis of 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbonitrile derivatives ( 4a–s) is investigated via a cascade reaction of aldehydes, malanonitrile and 2-aminopyridine in aqueous medium at 65 °C under u...

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Bibliographic Details
Published in:Catalysis letters 2017-03, Vol.147 (3), p.640-648
Main Authors: Ghorad, Akash, Mahalle, Sagar, Khillare, Lalit D., Sangshetti, Jaiprakash N., Bhosle, Manisha R.
Format: Article
Language:English
Subjects:
Aldehydes
Aqueous solutions
Biodegradability
Biomimetics
Cascade chemical reactions
Catalysis
Catalysts
Chemical synthesis
Chemistry
Chemistry and Materials Science
Cyclodextrins
Derivatives
Industrial Chemistry/Chemical Engineering
Organometallic Chemistry
Physical Chemistry
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Summary:Supramolecular β-cyclodextrin as a highly efficient, biodegradable, and reusable catalyst for the synthesis of 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbonitrile derivatives ( 4a–s) is investigated via a cascade reaction of aldehydes, malanonitrile and 2-aminopyridine in aqueous medium at 65 °C under ultrasonication. This procedure has the advantages of good yields, easy work-up, and benign environment friendly character. All of the synthesized derivatives were evaluated for their in vitro antibacterial activity against four bacterial strains. Graphical Abstract
ISSN:1011-372X
1572-879X
DOI:10.1007/s10562-017-1983-y