Novel and Efficient Heterogeneous 4-Methylbenzenesulfonic Acid-Based Ionic Liquid Supported on Silica Gel for Greener Fischer Indole Synthesis

In this work, a functionalizing active species 4-methylbenzenesulfonic acid-based IL on silica gel (IL-SO 3 H-SiO 2 ) has been prepared, and characterized by FT-IR, XRD, TGA, SEM and EDX spectra. Then, IL-SO 3 H-SiO 2 was utilized as an efficient and heterogeneous catalyst for the synthesis of indol...

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Bibliographic Details
Published in:Catalysis letters 2016-05, Vol.146 (5), p.968-976
Main Authors: Hu, Yu-Lin, Fang, Dong, Li, Dong-Sheng
Format: Article
Language:English
Subjects:
Aldehydes
Catalysis
Catalysts
Catalytic activity
Chemical synthesis
Chemistry
Chemistry and Materials Science
Hydrazines
Indoles
Industrial Chemistry/Chemical Engineering
Ionic liquids
Ions
Ketones
Organometallic Chemistry
Physical Chemistry
Reagents
Silica gel
Silicon dioxide
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Summary:In this work, a functionalizing active species 4-methylbenzenesulfonic acid-based IL on silica gel (IL-SO 3 H-SiO 2 ) has been prepared, and characterized by FT-IR, XRD, TGA, SEM and EDX spectra. Then, IL-SO 3 H-SiO 2 was utilized as an efficient and heterogeneous catalyst for the synthesis of indoles via the one-pot Fischer reaction of phenyl hydrazines with ketones or aldehydes at room temperature. The heterogeneous catalyst could be recovered easily by filtration and reused many times without significant loss of its catalytic activity. Graphical Abstract
ISSN:1011-372X
1572-879X
DOI:10.1007/s10562-016-1721-x