Antitumour activities of sanguinarine and related alkaloids

Sanguinarine is a best-known member of a relatively small group of quaternary benzo[c]phenanthridine alkaloids (QBAs). QBAs are widely distributed in the family Papaveraceae and, to a limited extent, in some species of the families Fumariaceae and Rutaceae. From a medical perspective, QBAs have many...

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Bibliographic Details
Published in:Phytochemistry reviews 2014-03, Vol.13 (1), p.51-68
Main Authors: Slaninová, Iva, Pěnčíková, Kristýna, Urbanová, Jana, Slanina, Jiří, Táborská, Eva
Format: Article
Language:English
Subjects:
Alkaloids
anti-inflammatory activity
Anticancer properties
Biochemistry
Biomedical and Life Sciences
Chemistry/Food Science
DNA
enzymes
Fungicides
Inflammation
Life Sciences
Microtubules
Organic Chemistry
Papaveraceae
Phenanthridine
Plant Genetics and Genomics
Plant Sciences
Rutaceae
Sanguinarine
therapeutics
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Summary:Sanguinarine is a best-known member of a relatively small group of quaternary benzo[c]phenanthridine alkaloids (QBAs). QBAs are widely distributed in the family Papaveraceae and, to a limited extent, in some species of the families Fumariaceae and Rutaceae. From a medical perspective, QBAs have many important properties. In addition to antitumour activity, they display antimicrobial, antifungal and anti-inflammatory effects. They may interact with many targets, such as DNA and microtubules, and they modify the activities of a wide variety of enzymes. This review summarises the current state of knowledge about the properties of QBAs that are important for their potential use in anticancer therapy.
ISSN:1568-7767
1572-980X
DOI:10.1007/s11101-013-9290-8