Serine protease inhibitors in plants: nature’s arsenal crafted for insect predators

• Published in: Phytochemistry reviews 2013-03, Vol.12 (1), p.1-34
• Main Authors: Jamal, Farrukh, Pandey, Prabhash K, Singh, Dushyant, Khan, M. Y
• Format: Article
• Language: English
• Subjects: Antiretroviral drugs; Biochemistry; Biomedical and Life Sciences; Chemistry/Food Science; Crop management; crops; defense mechanisms; digestive system; Host plants; insect pests; Insects; Life Sciences; mechanism of action; metabolism; Mode of action; Nutrients; Organic Chemistry; Pest control; pest management; Pests; Plant Genetics and Genomics; Plant Sciences; Predators; Protease; Protease inhibitors; Proteinase; Proteinase inhibitors; Proteins; Serine; Serine proteinase; Serine proteinase inhibitors; serine proteinases; Symbionts; Transgenic plants
• ISSN: 1568-7767; 1572-980X
• DOI: 10.1007/s11101-012-9231-y

Plant serine protease inhibitors are defense proteins crafted by nature for inhibiting serine proteases. Use of eco-friendly, sustainable and effective protein molecules which could halt or slow down metabolism of nutrients in pest would be a pragmatic approach in insect pest management of crops. The host-pest complexes that we observe in nature are evolutionary dynamic and inter-depend on other defense mechanisms and interactions of other pests or more generally speaking symbionts with the same host. Insects have co-evolved and adapted simultaneously, which makes it necessary to investigate serine protease inhibitors in non-host plants. Such novel serine protease inhibitors are versatile candidates with vast potential to overcome the host inhibitor-insensitive proteases. In a nutshell exploring and crafting plant serine proteinase inhibitors (PIs) for controlling pests effectively must go on. Non-host PI seems to be a better choice for coevolved insensitive proteases. Transgenic plants expressing wound inducible chimaeric PIs may be an outstanding approach to check wide spectrum of gut proteinases and overcome the phenomenon of resistance development. Thus, this article focuses on an entire array of plant serine protease inhibitors that have been explored in the past decade, their mode of action and biological implications as well as applications.