Walking Mechanics and Movement Pattern Variability in Monozygotic Twins with Autism Spectrum Disorder

The study of monozygotic (MZ) twins enables researchers to understand the inheritability and manifestation of many disorders due to the presence of near identical genotypes. It is reasonable to speculate that the heterogeneous manifestations of Autism Spectrum Disorder (ASD) present unique movement...

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Published in:Journal of developmental and physical disabilities 2018-12, Vol.30 (6), p.793-805
Main Authors: Dufek, Janet S., Harry, John R., Eggleston, Jeffrey D., Hickman, Robbin A.
Format: Article
Language:English
Subjects:
Autism
Autism Spectrum Disorders
Behavioral Science and Psychology
Child and School Psychology
Gait
Genotypes
Mechanics
Monozygotic
Original Article
Pediatrics
Pervasive developmental disorders
Precision medicine
Psychology
Public Health
Twins
Variability
Walking
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creator Dufek, Janet S.
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description The study of monozygotic (MZ) twins enables researchers to understand the inheritability and manifestation of many disorders due to the presence of near identical genotypes. It is reasonable to speculate that the heterogeneous manifestations of Autism Spectrum Disorder (ASD) present unique movement challenges to each MZ twin, regardless of nearly identical genotypes. However, such a study has yet to be performed. Additionally, no study has attempted to quantify the movement dysfunctions previously observed in this population. The purpose of this investigation was to examine gait parameters and movement pattern variability within one pair of monozygotic (MZ) twins diagnosed with ASD. One nine-year old pair of MZ twins with clinical diagnoses of ASD walked over-ground while kinetic and kinematic gait parameters were obtained. Point-by-point statistical and effect size (ES) analyses were performed throughout the gait cycle between twins. Movement pattern variability was quantified to explain the mechanical differences observed. Significant, (α 
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subjects Autism
Autism Spectrum Disorders
Behavioral Science and Psychology
Child and School Psychology
Gait
Genotypes
Mechanics
Monozygotic
Original Article
Pediatrics
Pervasive developmental disorders
Precision medicine
Psychology
Public Health
Twins
Variability
Walking
title Walking Mechanics and Movement Pattern Variability in Monozygotic Twins with Autism Spectrum Disorder
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