Biocompatible nanoclusters of O-carboxymethyl chitosan-coated Fe3O4 nanoparticles: synthesis, characterization and magnetic heating efficiency

In this work, we developed a polymer encapsulation of Fe 3 O 4 nanoparticles as a core–shell nanocluster with different sizes to investigate the cluster structure effect on their magnetic properties and magnetic heating behavior. Well-dispersed nanoclusters of O -carboxymethyl chitosan-coated Fe 3 O...

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Bibliographic Details
Published in:Journal of materials science 2018-06, Vol.53 (12), p.8887-8900
Main Authors: Linh, P. H., Chien, N. V., Dung, D. D., Nam, P. H., Hoa, D. T., Anh, N. T. N., Hong, L. V., Phuc, N. X., Phong, P. T.
Format: Article
Language:English
Subjects:
Biocompatibility
Characterization and Evaluation of Materials
Chemical Routes to Materials
Chemical synthesis
Chemistry and Materials Science
Chitosan
Classical Mechanics
Clusters
Crystallography and Scattering Methods
Heating
Hyperthermia
Iron oxides
Magnetic properties
Magnetic saturation
Magnetism
Materials Science
Nanoclusters
Nanoparticles
Polymer Sciences
Solid Mechanics
Toxicity
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Summary:In this work, we developed a polymer encapsulation of Fe 3 O 4 nanoparticles as a core–shell nanocluster with different sizes to investigate the cluster structure effect on their magnetic properties and magnetic heating behavior. Well-dispersed nanoclusters of O -carboxymethyl chitosan-coated Fe 3 O 4 nanoparticles were synthesized by microwave-assisted co-precipitation. The cluster sizes were tunable by varying the concentration of polymers used during synthesis. Nanoclusters present superparamagnetic behavior at room temperature with a reduction in saturation magnetization as a consequence of coating layer. The shift of blocking temperature to the higher value with increasing clusters size shows the stronger magnetic interaction in larger magnetic clusters. In a low alternating magnetic field with frequency of 178 Hz and amplitude of 103 Oe, nanoclusters offer a high heating efficiency. A maximum specific absorption rate of 204 W/g is observed in the sample with hydrodynamic size of 53 nm. In vitro cytotoxicity analysis performed on HeLa cells verified that nanoclusters show a good biocompatibility and can be an excellent candidate for applications in hyperthermia cancer treatment.
ISSN:0022-2461
1573-4803
DOI:10.1007/s10853-018-2180-0