Hollow silica–polyelectrolyte composite nanoparticles for controlled drug delivery

The stimulus-responsive drug delivery system has attracted increasing attention due to its ability to enhance therapeutic efficacy and reduce side effects. Herein, a pH and glutathione (GSH) dually responsive drug carrier, hollow silica–-polyelectrolyte composite nanoparticle, was successfully prepa...

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Bibliographic Details
Published in:Journal of materials science 2019-02, Vol.54 (3), p.2552-2565
Main Authors: Yang, Qingsong, Li, Li, Zhao, Fang, Han, Haoya, Wang, Weihua, Tian, Yuchuan, Wang, Yunwei, Ye, Zhishuang, Guo, Xuhong
Format: Article
Language:English
Subjects:
Acrylic acid
Characterization and Evaluation of Materials
Chemistry and Materials Science
Classical Mechanics
Crystallography and Scattering Methods
Doxorubicin
Drug carriers
Drug delivery systems
Glutathione
Materials for Life Sciences
Materials Science
Nanoparticles
Photon correlation spectroscopy
Polyelectrolytes
Polymer Sciences
Polystyrene resins
Side effects
Silicon dioxide
Small angle X ray scattering
Solid Mechanics
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Summary:The stimulus-responsive drug delivery system has attracted increasing attention due to its ability to enhance therapeutic efficacy and reduce side effects. Herein, a pH and glutathione (GSH) dually responsive drug carrier, hollow silica–-polyelectrolyte composite nanoparticle, was successfully prepared by using a template of spherical polyelectrolyte brush (SPB) which consists of a polystyrene (PS) core and a densely grafted linear poly(acrylic acid) (PAA) shell. The existence of PAA chains and introduction of disulfide bonds in silica framework endow the composite nanoparticles with pH and GSH dually responsive properties which were confirmed by dynamic light scattering (DLS) and small-angle X-ray scattering (SAXS). With doxorubicin hydrochloride (DOX) as the model drug, the loading content and encapsulation efficiency could reach up to 43% and 96%, respectively. The drug release behavior was investigated under various environments, showing that the drug release rate increased with the decrease in pH value and the increase in GSH concentration. The prepared hollow SiO 2 –PAA composite nanoparticles possess a great potential as carriers for controlled drug delivery.
ISSN:0022-2461
1573-4803
DOI:10.1007/s10853-018-2996-7