Crosslinking of poly(vinyl alcohol) nanofibres with polycarboxylic acids: biocompatibility with human skin keratinocyte cells

In this study, poly(vinyl alcohol) nanofibres were produced and evaluated for wound dressing applications. However, the solubility of the poly(vinyl alcohol) matrix in the aqueous medium generally limits its applications. To overcome this problem, 1,2,3,4 butanetetracarboxylic acid (BTCA) and citric...

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Bibliographic Details
Published in:Journal of materials science 2017-10, Vol.52 (20), p.12098-12108
Main Authors: Çay, Ahmet, Akçakoca Kumbasar, E. Perrin, Keskin, Zalike, Akduman, Çiğdem, Şendemir Ürkmez, Aylin
Format: Article
Language:English
Subjects:
Alcohol
Aqueous solutions
Biocompatibility
Biomaterials
Characterization and Evaluation of Materials
Chemistry and Materials Science
Citric acid
Classical Mechanics
Crosslinking
Crystallography and Scattering Methods
Fibrous structure
Materials Science
Morphology
Nanofibers
Organic acids
Polycarboxylic acids
Polymer crosslinking
Polymer Sciences
Skin
Solid Mechanics
Toxicity
Water treatment
Wound healing
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Summary:In this study, poly(vinyl alcohol) nanofibres were produced and evaluated for wound dressing applications. However, the solubility of the poly(vinyl alcohol) matrix in the aqueous medium generally limits its applications. To overcome this problem, 1,2,3,4 butanetetracarboxylic acid (BTCA) and citric acid (CA) were used as crosslinking agents. Successful bead-free nanofibres were produced, and they both preserved their fibrous structure after water treatment. The mean fibre diameters of polycarboxylic acid crosslinked nanofibres were lower compared to pure PVA nanofibres. Although the morphology of BTCA and CA crosslinked nanofibres was similar, the swelling degree of PVA/CA was found to be higher. Furthermore, toxicity and keratinocyte cell proliferation performance of produced PVA/BTCA and PVA/CA nanofibres indicated that these nanofibrous materials could be used in wound dressing applications.
ISSN:0022-2461
1573-4803
DOI:10.1007/s10853-017-1370-5