Effective diffusivities of BSA in cellulosic fiber beds measured with magnetic resonance imaging

The temporal and spatial evolution of concentration profiles of bovine serum albumin (BSA) in various cellulosic fiber beds is measured using magnetic resonance imaging. Effective diffusivities are calculated using a numerical one dimensional Fickian model to match experimental concentration profile...

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Bibliographic Details
Published in:Cellulose (London) 2012-08, Vol.19 (4), p.1085-1095
Main Authors: Lavenson, David M., Tozzi, Emilio J., McCarthy, Michael J., Powell, Robert L.
Format: Article
Language:English
Subjects:
Adsorption
Bioorganic Chemistry
Cellulose fibers
Ceramics
Chemistry
Chemistry and Materials Science
Composites
Fibre beds
Glass
Magnetic resonance imaging
Natural Materials
NMR
Nuclear magnetic resonance
Organic Chemistry
Original Paper
Physical Chemistry
Polymer Sciences
Porosity
Predictions
Serum albumin
Sustainable Development
Tortuosity
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Summary:The temporal and spatial evolution of concentration profiles of bovine serum albumin (BSA) in various cellulosic fiber beds is measured using magnetic resonance imaging. Effective diffusivities are calculated using a numerical one dimensional Fickian model to match experimental concentration profiles. Experimental values of the diffusivities are compared with predictions from a simple diffusion-adsorption model which accounts for porosity, tortuosity, and surface adsorption. BSA was found to have negligible adsorption in the concentration range studied, resulting in a simplified diffusion model based on fiber characteristics and geometry. Effective diffusivities agreed well with the predicted values and were within an order of magnitude of the estimated bulk diffusivity of BSA.
ISSN:0969-0239
1572-882X
DOI:10.1007/s10570-012-9732-2