Surfactant effects on the particle size, zeta potential, and stability of starch nanoparticles and their use in a pH-responsive manner

Storage conditions seem to be important in the long-term stability of nanoparticles (NPs). This work studies the effects of surfactants and storage container on particle size distribution and zeta potential during long-term storage of acid hydrolyzed potato starch NPs. The NPs were prepared from pot...

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Bibliographic Details
Published in:Cellulose (London) 2017-10, Vol.24 (10), p.4217-4234
Main Authors: Masoudipour, Elham, Kashanian, Soheila, Azandaryani, Abbas Hemati, Omidfar, Kobra, Bazyar, Elham
Format: Article
Language:English
Subjects:
Bioorganic Chemistry
Carbon dioxide
Ceramics
Chemistry
Chemistry and Materials Science
Composites
Containers
Corn
Drug delivery systems
Glass
Nanoparticles
Natural Materials
Organic Chemistry
Original Paper
Particle size
Particle size distribution
Physical Chemistry
Polymer Sciences
Potatoes
Sodium bicarbonate
Stability analysis
Surfactants
Sustainable Development
Ultrasonic processing
Zeta potential
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Summary:Storage conditions seem to be important in the long-term stability of nanoparticles (NPs). This work studies the effects of surfactants and storage container on particle size distribution and zeta potential during long-term storage of acid hydrolyzed potato starch NPs. The NPs were prepared from potato starch using acid hydrolysis and high-intensity ultrasonication. During the ultrasonic treatment, the surfactants were added dropwise to the solutions to reduce the size and stabilize the formed NPs. Particle size distribution, zeta potential, and FE-SEM were used to characterize the ensuing NPs. Additionally, a 5-month stability study was performed to evaluate the maintenance of potato starch NPs over time at different storage conditions. Then, NPs from corn starch were produced by the same procedure and were used for preparing pH-responsive nanocarriers containing NaHCO 3 for delivery of an anti-cancer drug, FTY720. These NPs were able to release the drug at pH 5.0 because of CO 2 generated from NaHCO 3 in acidic pH and released from the NPs by the production of pores, which accelerate drug release.
ISSN:0969-0239
1572-882X
DOI:10.1007/s10570-017-1426-3