Hybrid scaffolds enhanced by nanofibers improve in vitro cell behavior for tissue regeneration

To construct a biomimetic scaffold with a nanoscale structure similar to that of natural tissue, the objective of this work was to prepare three-dimensional (3D) porous hybrid scaffolds based on gelatin and bacterial cellulose nanofibers for tissue regeneration. The nanofibrous structure, water abso...

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Bibliographic Details
Published in:Cellulose (London) 2018-12, Vol.25 (12), p.7113-7125
Main Authors: Wang, Baoxiu, Huang, Chengsheng, Chen, Shiyan, Xing, Xueyu, Zhang, Minghao, Wu, Qingkai, Wang, Huaping
Format: Article
Language:English
Subjects:
Biomimetics
Bioorganic Chemistry
Ceramics
Chemistry
Chemistry and Materials Science
Composites
Endothelial cells
Gelatin
Glass
Mechanical properties
Morphology
Nanofibers
Natural Materials
Organic Chemistry
Original Paper
Physical Chemistry
Polymer Sciences
Regeneration
Scaffolds
Skin
Stiffness
Sustainable Development
Tissue engineering
Viability
Water absorption
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Summary:To construct a biomimetic scaffold with a nanoscale structure similar to that of natural tissue, the objective of this work was to prepare three-dimensional (3D) porous hybrid scaffolds based on gelatin and bacterial cellulose nanofibers for tissue regeneration. The nanofibrous structure, water absorption, and compressive mechanical properties of the scaffolds were studied. The hybrid scaffolds not only give a sufficiently porous structure for efficient nutrient transport and vascularization, but also provide the nanofibrous structure and improve the roughness of the scaffold pore walls. The hybrid scaffolds also exhibit higher modulus as stiffness compared to the pure gelatin scaffold. The viability and morphology of Pig iliac endothelial cells (PIECs) cultured on the 3D scaffolds were examined. PIECs adhered and proliferated better on the stiff hybrid scaffold with nanofibers compared to the soft gelatin scaffold without nanofibers. The results addressed the effect of the nanofibers and the stiffness of scaffolds on cell behavior, and the biomimetic nanofibrous hybrid scaffolds would be highly favorable/desired for tissue regeneration, e.g., skin and urethral regeneration. Graphical Abstract
ISSN:0969-0239
1572-882X
DOI:10.1007/s10570-018-2087-6