Lupane Triterpenoids and New Derivatives as Antiproliferative Agents Against Prostate Cancer Cells

This study examined the potential role of natural triterpenoids lupeol, calenduladiol and heliantriol B2, and a set of 19 derivatives, as antiproliferative and antimetastatic agents against prostate cancer cells. Natural triterpenoids were isolated from Chuqiraga erinaceae. Analogs were obtained by...

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Bibliographic Details
Published in:Anticancer research 2019-07, Vol.39 (7), p.3835-3845
Main Authors: Castro, María Julia, Careaga, Valeria Pilar, Sacca, Paula Alejandra, Faraoni, María Belén, Murray, Ana Paula, Calvo, Juan Carlos
Format: Article
Language:English
Subjects:
Antineoplastic Agents - pharmacology
Antiproliferatives
Cell Line, Tumor
Cell migration
Cell Proliferation - drug effects
Cytotoxicity
Derivatives
Humans
Male
Prostate cancer
Prostatic Neoplasms - drug therapy
Sulfates
Triterpenes - pharmacology
Triterpenoids
Wound healing
Wound Healing - drug effects
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Summary:This study examined the potential role of natural triterpenoids lupeol, calenduladiol and heliantriol B2, and a set of 19 derivatives, as antiproliferative and antimetastatic agents against prostate cancer cells. Natural triterpenoids were isolated from Chuqiraga erinaceae. Analogs were obtained by transformations of lupeol and calenduladiol. The effects of compounds on PC-3 and LNCaP cells were determined using the MTT assay. Compounds with half-maximal inhibitory concentration
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.13533