Selenium-Rich Yeast Mitigates Aluminum-Mediated Testicular Toxicity by Blocking Oxidative Stress, Inhibiting NO Production, and Disturbing Ionic Homeostasis

Aluminum (Al) poisoning has been linked to the development of several reproductive system dysfunctions. Dietary supplementation with selenium-rich yeast (SeY) has been shown to prevent a variety of pathologic conditions. In the present study, the potential protect role of SeY on Al-induced testicula...

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Bibliographic Details
Published in:Biological trace element research 2020-05, Vol.195 (1), p.170-177
Main Authors: Cao, Changyu, Zhang, Haoji, Wang, Kai, Li, Xinran
Format: Article
Language:English
Subjects:
Aluminium
Aluminum
Aluminum - toxicity
Animals
Biochemistry
Biological stress
Biomedical and Life Sciences
Biotechnology
Dietary supplements
Histopathology
Homeostasis
Homeostasis - drug effects
Life Sciences
Male
Mice
Mice, Inbred Strains
Nitric Oxide - antagonists & inhibitors
Nitric Oxide - biosynthesis
Nutrition
Oncology
Oxidative stress
Oxidative Stress - drug effects
Pathology
Reproductive system
Saccharomyces cerevisiae - chemistry
Selenium
Selenium - administration & dosage
Selenium - pharmacology
Testes
Testis - drug effects
Testis - metabolism
Toxicity
Yeast
Yeasts
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Summary:Aluminum (Al) poisoning has been linked to the development of several reproductive system dysfunctions. Dietary supplementation with selenium-rich yeast (SeY) has been shown to prevent a variety of pathologic conditions. In the present study, the potential protect role of SeY on Al-induced testicular toxicity was evaluated, and the possible underlying mechanisms were discussed. Mice were treated with SeY (0.1 mg/kg) and/or Al (10 mg/kg) by oral gavage for 4 weeks. Histopathologic changes were observed in the testes of Al-treated mice. Oxidative stress, ionic disturbances, and the generation of NO systems are believed to have resulted in the observed pathology. Interestingly, SeY supplementation significantly inhibited the Al-induced histopathological and molecular changes and restored these indicators to levels observed in the control animals. These results suggest that SeY exerts a testis-protective effect against Al-induced toxicity through the reduction of oxidative stress, NO production, and the maintenance of ionic homeostasis.
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-019-01820-5