Association of Non-Invasive Markers of Liver Fibrosis with HCV Coinfection and Antiretroviral Therapy in Patients with HIV

• Published in: Proceedings of the Latvian Academy of Sciences. Section B, Natural Sciences Natural Sciences, 2019-08, Vol.73 (4), p.400-402
• Main Authors: Koļesova, Oksana, Eglīte, Jeļena, Koļesovs, Aleksandrs, Krūmiņa, Angelika, Ekšteina, Ilze, Madelāne, Monta, Vīksna, Ludmila
• Format: Article
• Language: English
• Subjects: Alanine; Alanine transaminase; ALT; Antiretroviral agents; Antiretroviral drugs; Antiretroviral therapy; Aspartate aminotransferase; AST; Drug therapy; Females; FIB-4; Fibrosis; Hepatitis; Hepatitis C; HIV; Human immunodeficiency virus; Hyaluronic acid; Liver; liver fibrosis; Markers; Mathematical analysis; Matrix metalloproteinase; Matrix metalloproteinases; Metalloproteinase; nonparametric ANOVA; Nonparametric statistics; pro-MMP-1; Therapy; Variance analysis
• ISSN: 1407-009X; 2255-890X; 1407-009X
• DOI: 10.2478/prolas-2019-0062

The aim of this study was to assess the main effects and interaction between viral hepatitis C (HCV) coinfection and antiretroviral therapy (ART) by using a nonparametric ANOVA on direct and indirect markers of liver fibrosis in HIV-infected patients. The sample included 178 HIV patients aged from 23 to 65 (36% females). The following parameters were determined in blood of patients: hyaluronic acid, pro-matrix metalloproteinase-1, alanine aminotransferase, aspartate aminotransferase, and platelet count. The FIB-4 index was also calculated. The nonparametric ANOVA revealed no significant interaction between HCV coinfection and ART. This provides evidence for an independent contribution of each factor on promotion of the pathology. The results also demonstrated that the direct and indirect indicators of liver fibrosis are associated differently with the studied factors. Therefore, a combination of markers should be used for monitoring of liver fibrosis in HIV-infected patients.