RETRACTED ARTICLE: Progesterone effects on preterm birth in high-risk pregnancies: a randomized placebo-controlled trial

Purpose The purpose of this study was to evaluate whether the prophylactic administration of vaginal progesterone would reduce the preterm birth rate in high-risk population including singleton and twin pregnancies. Methods This was a randomized, double blind, placebo-controlled study that included...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2011-03, Vol.283 (3), p.423-429
Main Authors: Cetingoz, Elcin, Cam, Cetin, Sakallı, Mustafa, Karateke, Ates, Celik, Cem, Sancak, Ali
Format: Article
Language:English
Subjects:
Endocrinology
Gynecology
Human Genetics
Materno-fetal Medicine
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
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Summary:Purpose The purpose of this study was to evaluate whether the prophylactic administration of vaginal progesterone would reduce the preterm birth rate in high-risk population including singleton and twin pregnancies. Methods This was a randomized, double blind, placebo-controlled study that included 150 high-risk pregnancies. Risk groups included prior spontaneous preterm birth, twin pregnancy, and uterine malformation. Micronized progesterone or placebo (100 mg) was administered daily by vaginal suppository between 24 and 34 weeks of gestation. We compared progesterone and placebo groups for incidence of preterm labor and preterm delivery. Data were compared by χ ² analysis and Fisher exact test. Results There was a statistically significant difference in the rate of preterm labor between placebo and progesterone groups (45.7 vs. 25%, respectively; p  
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-009-1351-2