Successful pregnancy involving a man with chronic myeloid leukemia on dasatinib

Dasatinib is a highly potent Bcr-Abl inhibitor that is approved for the treatment of imatinib-resistant or -intolerant chronic myeloid leukemia (CML). The potential effects of dasatinib on sperm counts, sperm function, and fertility have not been studied yet. There is only one report in the medical...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2011, Vol.283 (1), p.133-134
Main Authors: Oweini, Houssam, Otrock, Zaher K., Mahfouz, Rami A. R., Bazarbachi, Ali
Format: Article
Language:English
Subjects:
Adult
Antineoplastic Agents - adverse effects
Antineoplastic Agents - therapeutic use
Dasatinib
Endocrinology
Female
Fertilization - drug effects
Gynecology
Human Genetics
Humans
Infant
Letter to the Editor
Leukemia
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy
Male
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Pregnancy
Protein Kinase Inhibitors - adverse effects
Protein Kinase Inhibitors - therapeutic use
Pyrimidines - adverse effects
Pyrimidines - therapeutic use
Sperm
Thiazoles - adverse effects
Thiazoles - therapeutic use
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Summary:Dasatinib is a highly potent Bcr-Abl inhibitor that is approved for the treatment of imatinib-resistant or -intolerant chronic myeloid leukemia (CML). The potential effects of dasatinib on sperm counts, sperm function, and fertility have not been studied yet. There is only one report in the medical literature of successful pregnancies while patients were taking dasatinib, thus making our case the second report. Here, we present the case of a 38-year-old man who conceived a healthy baby while on dasatinib therapy.
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-010-1501-6