A comparative study of genotoxic effects in the treatment of trichomonas vaginalis infection: metronidazole or nalidixic acid

We performed a prospective randomized study to compare the potential genotoxic effects of metronidazole and nalidixic acid which they are used in the treatment of Trichomonas vaginalis infection. 20 patients with Trichomonas vaginalis infections participated in this study. 14 patients with vaginal t...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2000-07, Vol.264 (1), p.20-23
Main Authors: Akyol, D, Mungan, T, Baltaci, V
Format: Article
Language:English
Subjects:
Acids
Adult
Animals
Antitrichomonal Agents - therapeutic use
Condoms
Female
Gene Frequency
Genes - drug effects
Humans
Infections
Metronidazole - therapeutic use
Middle Aged
Mutagenicity Tests
Nalidixic Acid - therapeutic use
Parasitic diseases
Prospective Studies
Sexually transmitted diseases
Sister Chromatid Exchange
STD
Trichomonas vaginalis - genetics
Trichomonas Vaginitis - drug therapy
Trichomonas Vaginitis - parasitology
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Summary:We performed a prospective randomized study to compare the potential genotoxic effects of metronidazole and nalidixic acid which they are used in the treatment of Trichomonas vaginalis infection. 20 patients with Trichomonas vaginalis infections participated in this study. 14 patients with vaginal trichomoniasis were treated with therapeutic doses of metronidazole 250 mg 3 times/d and six patients were treated with nalidixic acid 400 mg twice a day for 10 d. The genotoxic potential of a variety of mutagenic and carcinogenic agents can be evaluated by sister-chromatid exchange (SCE) test as a rapid cytogenetic test. An increased number of exchanges in lymphocytes reflects the influence of mutagens. No significant difference was observed in the SCE frequency of metronidazole treated patient however, a statistically significant increase (P
ISSN:0932-0067
1432-0711
DOI:10.1007/PL00007476