The effects of laser energy density and particle size in the selective laser sintering of polycaprolactone/progesterone specimens: morphology and drug release

The goals of this work were to fabricate specimens of different powder particle sizes and laser energy density of polycaprolactone and progesterone by selective laser sintering and evaluate the morphology by scanning electron microscopy and the mechanism of drug release in vitro. The results showed...

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Bibliographic Details
Published in:International journal of advanced manufacturing technology 2013-05, Vol.66 (5-8), p.1113-1118
Main Authors: Salmoria, Gean Vitor, Klauss, Priscila, Zepon, Karine Modolon, Kanis, Luiz Alberto
Format: Article
Language:English
Subjects:
CAE) and Design
Coalescing
Computer-Aided Engineering (CAD
Drug delivery systems
Engineering
Erosion
Flux density
Industrial and Production Engineering
Laser sintering
Mechanical Engineering
Media Management
Morphology
Original Article
Polycaprolactone
Rapid prototyping
Scanning electron microscopy
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Summary:The goals of this work were to fabricate specimens of different powder particle sizes and laser energy density of polycaprolactone and progesterone by selective laser sintering and evaluate the morphology by scanning electron microscopy and the mechanism of drug release in vitro. The results showed that the specimens maintained morphological uniformity, coalescence of particles, and interconnected pores distributed in the sintered structure. The drug release mechanism of all specimens studied followed a zero-order kinetics, and drug release rates were dependent on sintering degree and, consequently, on matrix erosion.
ISSN:0268-3768
1433-3015
DOI:10.1007/s00170-012-4393-8