The role of oxidative stress in ovarian toxicity induced by haloperidol and clozapine—a histological and biochemical study in albino rats

Oxidative stress has been implicated in reproductive toxicity induced by antipsychotics (APs). This study aims to further investigate the role of AP-induced oxidative stress in reproductive dysfunction. Thirty adult female albino rats were divided into three groups including a control group ( n  = 1...

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Bibliographic Details
Published in:Cell and tissue research 2019-11, Vol.378 (2), p.371-383
Main Authors: Khalaf, Hanaa Attia, Elmorsy, Ekramy, Mahmoud, El-Hassanin Mohamed, Aggour, Amal Misbah, Amer, Saad A.
Format: Article
Language:English
Subjects:
Albinism
Animals
Antipsychotics
Biomedical and Life Sciences
Biomedicine
Catalase
Catalase - metabolism
Clozapine
Clozapine - toxicity
Ethylenediaminetetraacetic acid
Female
Glutathione
Glutathione - metabolism
Haloperidol
Haloperidol - toxicity
Human Genetics
Hyperprolactinemia
Immunohistochemistry
Lipid peroxidation
Mitochondria
Mitochondria - drug effects
Mitochondria - metabolism
Molecular Medicine
Ovaries
Ovary - drug effects
Ovary - metabolism
Oxidation
Oxidative Stress
p53 Protein
Prolactin
Proteomics
Psychotropic drugs
Rats
Rats, Wistar
Regular Article
Superoxide Dismutase - metabolism
Toxicity
Tumor proteins
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Summary:Oxidative stress has been implicated in reproductive toxicity induced by antipsychotics (APs). This study aims to further investigate the role of AP-induced oxidative stress in reproductive dysfunction. Thirty adult female albino rats were divided into three groups including a control group ( n  = 10) receiving distilled water, HAL group ( n  = 10) receiving haloperidol (HAL) (2 mg/kg/day), and CLZ group ( n  = 10) receiving clozapine (CLZ) (20 mg/kg/day). After 28 days, the rats were anesthetized, blood was withdrawn from their hearts, and ovaries were removed before they were sacrificed. Serum prolactin concentrations were measured. For each rat, one ovary was used for biochemical studies including mitochondrial complexes I and III activities and oxidative stress markers (lipid peroxidation, super oxide dismutase [SOD], catalase [CAT], and reduced glutathione [GSH]). The other ovary was used for histopathological examination and immunohistochemistry staining for p53 and Ki-67. HAL-treated rats showed significantly ( p  
ISSN:0302-766X
1432-0878
DOI:10.1007/s00441-019-03067-x