Trace level analysis of three glycol ethers in wood stains by APCI-LC-MS/MS

A direct injection liquid chromatography tandem atmospheric pressure chemical ionization mass spectrometry method was developed for the determination of diethylene glycol methyl ether (DEGME), dipropylene glycol butyl ether (DPGBE), and dipropylene glycol methyl ether (DPGME). This aqueous based met...

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Bibliographic Details
Published in:Analytical methods 2019-08, Vol.11 (29), p.3671-3677
Main Authors: MacInnis, Ceara, Brunswick, Pamela, Yan, Jeffrey, Kim, Marcus, Van Aggelen, Graham, Shang, Dayue
Format: Article
Language:English
Subjects:
Analytical chemistry
Daidzein
Diethylene glycol
Environmental protection
Ethers
Glycol ethers
Ionization
Ions
Linearity
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Organic chemistry
Propylene glycol
Propylene glycol ethers
Protective coatings
Quality assurance
Quality control
Regression analysis
Stains
Wood
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Summary:A direct injection liquid chromatography tandem atmospheric pressure chemical ionization mass spectrometry method was developed for the determination of diethylene glycol methyl ether (DEGME), dipropylene glycol butyl ether (DPGBE), and dipropylene glycol methyl ether (DPGME). This aqueous based method is suitable for many different applications, but was specifically applied to wood stains in the present study. Multiple reaction monitoring (MRM) mode was employed to quantify the glycol ethers by detection of the precursor to product transitions at 121.1 m / z 59.1 m / z (DEGME), 191.1 m / z 59.1 m / z (DPGBE), and 149.1 m / z 59.1 m / z (DPGME). Secondary qualifier ion transitions were used to confirm identity, and the daidzein internal standard demonstrated an excellent correlation to glycol ether responses. Method linearity by (1/ x ) linear weighted regression showed coefficients 0.995 in the ranges 0.5 ng mL 1 to 25 ng mL 1 , 2.5 ng mL 1 to 50 ng mL 1 , and 5.0 ng mL 1 to 50 ng mL 1 for DEGME, DPGBE, and DPGME respectively. A precision of
ISSN:1759-9660
1759-9679
DOI:10.1039/c9ay00739c