Alpha-tocopherol acetate nasal spray in the treatment of pollen-induced allergic rhinitis

BackgroundThis study compared the effectiveness and tolerability of alpha-tocopherol acetate nasal spray (ATANS) to those of beclomethasone nasal spray (BNS) and loratadine (LT) for the treatment of pollen-induced allergic rhinitis.MethodsThis active-controlled, patient-preference, observational tri...

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Bibliographic Details
Published in:Allergo journal international 2019-01, Vol.28 (5), p.152-159
Main Authors: Pieper-Fürst, Ursula, Van-Anh, Dao, Shah-Hosseini, Kija, Panin, Giorgio, Lamprecht, Jürgen, Ralph Mösges
Format: Article
Language:English
Subjects:
Endoscopy
Histamine
Nose
Rhinitis
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Summary:BackgroundThis study compared the effectiveness and tolerability of alpha-tocopherol acetate nasal spray (ATANS) to those of beclomethasone nasal spray (BNS) and loratadine (LT) for the treatment of pollen-induced allergic rhinitis.MethodsThis active-controlled, patient-preference, observational trial lasted 7 days. Tested variables were nasal symptoms, endoscopic examination, additional medications, general effectiveness, safety, and tolerability.ResultsOf 116 patients, 63 patients decided to use ATANS, 32 BNS and 21 LT. During the treatment, the mean daily rhinitis symptom score decreased significantly in all groups. The 7‑day mean score in the ATANS group (0.98) was comparable to that of the BNS group (0.92) and significantly higher than that of the LT group (0.70, P 
ISSN:2197-0378
DOI:10.1007/s40629-018-0086-7