4-(Het)aryl-4,7-dihydroazolopyrimidines and Their Tuberculostatic Activity

Structural analogs of a promising antituberculous agent, ethyl 5-methyl-7-(thiophen-2-yl)-4,7-dihydro[1,2,4]triazolo[1,5- a ]pyrimidine-6-carboxylate have been synthesized by three-component condensations of various aromatic or hetaromatic aldehydes with several β-dicarbonyl compounds (CH acids) and...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2019-06, Vol.55 (6), p.775-781
Main Authors: Titova, Yu. A., Filatova, E. S., Fedorova, O. V., Rusinov, G. L., Charushin, V. N.
Format: Article
Language:English
Subjects:
Aldehydes
Aromatic compounds
Carbonyl compounds
Chemistry
Chemistry and Materials Science
Organic Chemistry
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Summary:Structural analogs of a promising antituberculous agent, ethyl 5-methyl-7-(thiophen-2-yl)-4,7-dihydro[1,2,4]triazolo[1,5- a ]pyrimidine-6-carboxylate have been synthesized by three-component condensations of various aromatic or hetaromatic aldehydes with several β-dicarbonyl compounds (CH acids) and 1 H -1,2,4-triazol-5-amine or 1 H -pyrazol-5-amine. The obtained compounds have been evaluated for tuberculostatic activity, and structure-activity relations have been analyzed.
ISSN:1070-4280
1608-3393
DOI:10.1134/S107042801906006X