A Convenient One-Pot Synthesis and Nematicidal Activity of Nicotinic Acid Amides

Seven nicotinic acid amides were synthesized by condensation of nicotinic acid adsorbed on silica gel with different aromatic amines. The synthesized compounds were characterized by 1 H and 13 C NMR and IR spectroscopy and screened for their nematicidal activity against root knot nematode Meloidogyn...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2019-06, Vol.55 (6), p.845-851
Main Authors: Jain, N., Utreja, D., Dhillon, N. K.
Format: Article
Language:English
Subjects:
Amides
Amines
Aromatic compounds
Chemistry
Chemistry and Materials Science
Infrared spectroscopy
Mortality
Nematodes
Nicotinamide
Nicotinic acid
NMR
Nuclear magnetic resonance
Organic Chemistry
Review
Silica gel
Silicon dioxide
Synthesis
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Summary:Seven nicotinic acid amides were synthesized by condensation of nicotinic acid adsorbed on silica gel with different aromatic amines. The synthesized compounds were characterized by 1 H and 13 C NMR and IR spectroscopy and screened for their nematicidal activity against root knot nematode Meloidogyne incognita by egg hatching and mortality test. All compounds exhibited significant nematicidal potential as compared to control. Maximum egg hatching inhibition potential was exhibited by N -(4-bromophenyl)nicotinamide while N -(2,4,5-trichlorophenyl)nicotinamide showed the maximum mortality potential.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428019060150