The Influence of Long-Term Peroral Administration of Gold Nanoparticles with Various Sizes on the Liver, Spleen, and Lymph Nodes of Laboratory Rats and Their Progeny

The influence of long-term peroral injection of gold nanoparticles with various sizes on the liver, spleen, and lymph nodes of adult laboratory rats and their progeny was studied. The morphometric analysis was conducted using a µVizo-103 medical digital microviser. The conglomerated gold nanoparticl...

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Bibliographic Details
Published in:Optics and spectroscopy 2019-06, Vol.126 (6), p.681-686
Main Authors: Pakhomy, S. S., Bucharskaya, A. B., Maslyakova, G. N., Zlobina, O. V., Bugaeva, I. O., Navolokin, N. A., Mudrak, D. A., Khlebtsov, B. N., Bogatyrev, V. A., Khlebtsov, N. G.
Format: Article
Language:English
Subjects:
Activation
Biophotonics
Gestation
Gold
Laboratories
Lasers
Liver
Lymph
Lymphatic system
Macrophages
Nanoparticles
Optical Devices
Optics
Organs
Photonics
Physics
Physics and Astronomy
Progeny
Spleen
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Summary:The influence of long-term peroral injection of gold nanoparticles with various sizes on the liver, spleen, and lymph nodes of adult laboratory rats and their progeny was studied. The morphometric analysis was conducted using a µVizo-103 medical digital microviser. The conglomerated gold nanoparticles were detected in tissues via the dark-field microscopy. Gold nanoparticles with sizes of 2 and 50 nm were found to cause the mostly pronounced morphological alterations in organs that testifies to their size-dependent impact. The liver in a group receiving 50-nm gold particles exhibit noticeable dystrophy of hepatocytes and activation of a monocyte macrophage system. The spleen and lymph nodes reveal the activation of proliferation and differentiation of immunocompetent cells and macrophages. Peroral injection of gold particles during gestation of females led to an increase in a number of hepatocytes with necrobiotic changes as well as to elevated amount of non-parenchymatic elements in the liver of the progeny, especially in groups containing the 2- and 50-nm gold nanoparticles.
ISSN:0030-400X
1562-6911
DOI:10.1134/S0030400X19060195