Catalyst free Synthesis of Phenyl Hydrazones and their Biological Evaluation

[...]isonicotinoyl hydrazones are antitubercular; 4-hydroxybenzoic acid[(5-nitro-2-furyl)methylene]- hydrazide (nifuroxazide) is an intestinal antiseptic; 4fluorobenzoic acid[(5-nitro-2-furyl)methylene]hydraziand 2,3,4-pentanetrione-3-[4-[[(5-nitro-2furyl)methylene] hydrazino]carbonyl]phenyl] - hydr...

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Bibliographic Details
Published in:Asian Journal of Research in Chemistry 2018-03, Vol.11 (2), p.269-274
Main Authors: Suryawanshi, Vikas B., Momin, Kalimoddin I., Bondge, Abhay S., Dawale, Jairaj K.
Format: Article
Language:English
Subjects:
Acids
Antibiotics
Antimicrobial agents
Aromatic compounds
Biological activity
Carbonyl compounds
Carbonyls
Catalase
Catalysts
Chemical synthesis
Chromatography
Dextrose
Dilution
Ethanol
Glycerol
Hydrazines
Hydrazones
Inoculum
Methylene
Oleic acid
Tuberculosis
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Summary:[...]isonicotinoyl hydrazones are antitubercular; 4-hydroxybenzoic acid[(5-nitro-2-furyl)methylene]- hydrazide (nifuroxazide) is an intestinal antiseptic; 4fluorobenzoic acid[(5-nitro-2-furyl)methylene]hydraziand 2,3,4-pentanetrione-3-[4-[[(5-nitro-2furyl)methylene] hydrazino]carbonyl]phenyl] - hydrazone , which were synthesized in our Department, have antibacterial activity against both Staphylococcus aureus ATCC 29213 and Mycobacterium tuberculosis H37Rv at a concentration of 3.13 gg/mL. Biological Study: These all the synthesized aryl hydrazone derivatives were screened for biological activity, since its novel compounds and based on literature observations it can be very potential drug candidates for drug discovery programme. In-vitro Mycobacterium tuberculosis MABA assay The inoculum was prepared from fresh LJ medium resuspended in 7H9-S medium (7H9 broth, 0.1% casitone, 0.5% glycerol, albumin, dextrose, supplemented oleic acid, and catalase [OADC]), adjusted to a McFarland tube No. 1, and diluted 1:20; 100 pl was used as inoculum. The common procedure for preparation of aryl hydrazones, In round bottom flask charged with benzophenones (10 mmol), hydrazine hydrate (10 mmol) then ethanol and water ( 1:1, 20 ml) was added, resulting solution stirred refluxed for 5 h. After completion of the reaction (monitored by TLC) cooled to room temperature, then water was added (20 mL), solid was formed. In-vitro Mycobacterium tuberculosis MABA assay The inoculum was prepared from fresh LJ medium resuspended in 7H9-S medium (7H9 broth, 0.1% casitone, 0.5% glycerol, albumin, dextrose, supplemented oleic acid, and catalase [OADC]), adjusted to a McFarland tube No. 1, and diluted 1:20; 100 pl was used as inoculum.
ISSN:0974-4169
0974-4150
DOI:10.5958/0974-4150.2018.00050.0