Synthesis and biological evaluation of coumarin acetamide derivatives

Besides of this, some derivatives of coumarins can be used as anticancer5 or anti tumour activity agents because they have the ability to prevent cell growth. Here we reported synthesis of coumarin aceatmide derivatives by using N- acetyl glycine and salicyldehyde as starting material. Since glycine...

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Bibliographic Details
Published in:Asian Journal of Research in Chemistry 2018-03, Vol.11 (2), p.453-458
Main Authors: Momin, Kalimoddin I., Suryawanshi, Vikas B., Bondge, Abhay S., Dawale, Jairaj K.
Format: Article
Language:English
Subjects:
Anticancer properties
Anticoagulants
Antimicrobial agents
Biological activity
Chromatography
Coumarin
Derivatives
Glycine
Mode of action
Synthesis
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Summary:Besides of this, some derivatives of coumarins can be used as anticancer5 or anti tumour activity agents because they have the ability to prevent cell growth. Here we reported synthesis of coumarin aceatmide derivatives by using N- acetyl glycine and salicyldehyde as starting material. Since glycine is amino acid and its available abundant, we thought its good starting point for our ongoing research to start with with commercially available starting material. [...]the acetyl and bromo containing salicyldehyde also worked well. The derivatives 5i shown nice inhibition which is due to donating group on phenyl ring (6.25 pM), subsequently all other compound also shown good activity, the substitution pattern greatly affects the mode of action and binding pattern with cell in, Hence this is good starting point for the building the drug discovery programme in future, based on these results one can conclude that synthesis of coumarin acetamide derivatives are very important and its applications can be shown in various cell lines.
ISSN:0974-4169
0974-4150
DOI:10.5958/0974-4150.2018.00082.2