A Comparative study of Vilsmeier-Haack Formylation Reactions With Phenols Under Solvent Less And Solvent Conditions

After completion of the reaction, as checked by TLC, the reaction mixture is treated with 5% sodium thio sulphate solution, followed by the addition of pet ether. After completion of the reaction, as checked by TLC, the reaction mixture is treated with 5% sodium thio sulphate solution, followed by t...

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Bibliographic Details
Published in:Asian Journal of Research in Chemistry 2018-03, Vol.11 (2), p.409-412
Main Authors: Redamala, Roopa, Merugu, Ramchander, Rajanna, K.C.
Format: Article
Language:English
Subjects:
Aromatic compounds
Chromatography
Comparative studies
Green chemistry
Mortars (comminutors)
Phenols
Sodium
Solvents
Sulfates
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Summary:After completion of the reaction, as checked by TLC, the reaction mixture is treated with 5% sodium thio sulphate solution, followed by the addition of pet ether. After completion of the reaction, as checked by TLC, the reaction mixture is treated with 5% sodium thio sulphate solution, followed by the addition of pet ether. After completion of the reaction, as checked by TLC, the reaction mixture is treated with 5% sodium thio sulphate solution, followed by the addition of pet ether. Aromatic compounds such as Phenols derivatives underwent formylation under Vilsmeier- Haack conditions in good yields when treated with DMF/SOCl2 under solution phase under classical conditions and sonicator and as well as solvent free conditions when the reactants are grounded in a mortar with a pestle for about 20-30 min. and in microwave for about 30 secs to 1 min. [...]this green methodology could be employed in different VH reactions.
ISSN:0974-4169
0974-4150
DOI:10.5958/0974-4150.2018.00074.3