Studies on Synthesis of Aromatic Schiff Bases. Part-VI. Synthesis, Characterization and Biological Activity of Ketimines from 5-Chloro-2-hydroxy-4-methyl-acetophenone with substituted anilines

• Published in: Asian Journal of Research in Chemistry 2018-03, Vol.11 (2), p.312-318
• Main Authors: Salve, S. B., Patil, C. J., Mahajan, H. A.
• Format: Article
• Language: English
• Subjects: Acetophenone; Alcohol; Alcohols; Antimicrobial agents; Biological activity; Cancer; Ethanol; Functional groups; Fungicides; Imines; Nitrogen dioxide; Phenols; Solvents; Spectra; Studies; Synthesis; Toluene
• ISSN: 0974-4169; 0974-4150
• DOI: 10.5958/0974-4150.2018.00058.5

The solvents The solvents absolute alcohol(ethanol), toluene and methanol used for synthesis, TLC and spectra purpose were of the synthesis and spectroscopic grade. The typical UV-Vis Spectra for the series of Ketimines synthesized, S-I to S-VII, is depicted in the Fig.-1, is shown below, The typical FTIR Spectra for the series of Ketimines synthesized, S-I to S-VII, is depicted in the Fig.-2, is shown below, On the basis of the foregoing discussion and based on the TLC spectral observations, the structures of the synthesized compounds are assigned. The FTIR spectra of the studied Ketimines, S-I to S-VII, indicated the absorption at different frequencies as v-oh = 3100; VAr-C-H = 1562 and 1460; va-c-h = 2820 ; v>c=n= = V-NO2 = 1446 and 1367 and vc-ci = 810 and 772 for the respective functional groups as indicated. Antifungal Activity: After confirming the desired molecular studies, these Ketimines, S-I to S-VII, were studied for their antifungal activity by subjecting to in vitro antifungal activity against plant pathogenic fungi viz.