3‐(α‐Chlorobenzyl)quinoxalin‐2(1H)‐ones as Versatile Reagents for the Synthesis of 3‐Benzylquinoxalin‐2(1H)‐ones and Thiazoloquinoxalin‐4(5H)‐ones

Facile and efficient methods for the synthesis of 3‐benzylquinoxalin‐2(1H)‐ones and thiazolo[3,4‐a]quinoxalin‐4(5H)‐ones by the reaction of the readily available 3‐(α‐chlorobenzyl)quinoxalin‐2(1H)‐ones and thiourea have been developed, with multiple roles of the latter. Possible mechanisms are discu...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2019-08, Vol.56 (8), p.2221-2234
Main Authors: Mamedov, Vakhid A, Zhukova, Nataliya A, Syakaev, Victor V, Beschastnova, Tat'yana N, Kadyrova, Milyausha S, Isaeva, Anastasiya O, Mamedova, Sevil V, Gavrilova, Elena L, Latypov, Shamil K, Sinyashin, Oleg G
Format: Article
Language:English
Subjects:
Reagents
Synthesis
Online Access:Get full text
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Summary:Facile and efficient methods for the synthesis of 3‐benzylquinoxalin‐2(1H)‐ones and thiazolo[3,4‐a]quinoxalin‐4(5H)‐ones by the reaction of the readily available 3‐(α‐chlorobenzyl)quinoxalin‐2(1H)‐ones and thiourea have been developed, with multiple roles of the latter. Possible mechanisms are discussed. These two‐step sequences can be performed in a one‐pot manner to produce the desired products in moderate to high yields.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.3616