Extractive Spectrophotometric Determination of Ulipristal Acetate using Naphthol Blue Black

A thorough literature survey shows that LC-MS/MS8-9, HPLC-gradient10, HPLC-isocratic11 and UV7 methods were proposed to determine of ulipristal. [...]the current study reports development and validation of a flexible extractive spectrophotometric method for the determination of ulipristal in bulk dr...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2019, Vol.12 (3), p.1347-1352
Main Authors: Gorumutchu, Giri Prasad, Ratnakaram, Venkata Nadh
Format: Article
Language:English
Subjects:
Acids
Chemistry
Drug dosages
Methods
Pharmaceuticals
Pharmacy
Temperature
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Summary:A thorough literature survey shows that LC-MS/MS8-9, HPLC-gradient10, HPLC-isocratic11 and UV7 methods were proposed to determine of ulipristal. [...]the current study reports development and validation of a flexible extractive spectrophotometric method for the determination of ulipristal in bulk drug and tablet dosage formulations. [...]the linearity of the proposed analytical method was tested. [...]the above method which comprises naphthol blue black as a complexing agent can be applied to determine the quantity of Ulipristal acetate present in pure and tablet formulations. [...]this simple method could be used for routine analysis in quality control laboratories.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.5958/0974-360X.2019.00226.9