Pharmacological Evaluation of Leaf Extract of Terminalia   bellerica with Moringa   oleifera for its Synergistic Action on Anti-diabetic Activity and Anti-inflammatory Activity in Rats

• Published in: Research journal of pharmacy and technology 2019-03, Vol.12 (3), p.1181-1184
• Main Authors: Karishma, Sk, Lakshmi, K., Tony, D. Eswar, Babu, A. Narendra, Nadendla, Rama Rao
• Format: Article
• Language: English
• Subjects: Acids; Albinism; Analgesics; Animals; Antidiabetics; Chronic illnesses; Diabetes; Immune system; Inflammation; Pharmaceutical sciences; Phytochemicals; Ulcers
• ISSN: 0974-3618; 0974-360X; 0974-306X
• DOI: 10.5958/0974-360X.2019.00195.1

Many allopathic medicines are available for the treatment of diabetes, includes sulphonylureas, biguanides, meglitinides and thiazolidinediones but some how they have their own adverse effects like hypoglycemia, nausea, vomiting, hyponatremia, flatulence, diarrhea or constipation, alcohol flush, headache, weight gain, lactic acidosis, pernicious anemia, dyspepsia, dizziness and joint pain. [...]instead of allopathic drugs, herbal drugs are the best choice which is having fewer side effects and non toxic properties.2 Inflammation is the response to injury of cells and body tissues through different factors such as infections, chemicals, thermal and mechanical injuries.3 It can be classified as either acute or chronic, and involves a cascade of biochemical events comprising the local vascular system, the immune system, and different cell types found in the injured tissue. Acute inflammation is the initial response and is characterized by the increased movement of plasma and innate immune system cells, such as neutrophils and macrophages, from the blood into the injured tissues.4 Chronic inflammation concerns a progressive change in the type of cells present at the site of the inflammatory reaction and is characterized by simultaneous destruction and healing of the injured tissue. Sprague-dawely rats either both sex were divided into five groups containing five animals in each. * Group-1-Control Group (0.9% Normal saline 5ml/kg orally) * Group-2-Inducing group (60mg/kg of STZ i.p) * Group-3-Aqueous leaf extract of Terminalia bellerica (100mg/kg orally) * Group-4-Aqueous leaf extract of Terminalia bellerica and Moringa oleifera (100mg/kg orally) * Group-5-Standard group (500pg/kg of Glibenclamide orally) Streptozotocin Induced Diabetes: Diabetes was induced by single intraperitoneal injection of a freshly prepared solution of STZ at a dose of 60 mg/kg bodyweight.7 Diabetes was developed and stabilized in STZ treated rats over a period of 7days.