Porphyrin-mediated binding to hemoglobin by the HA2 domain of cystein proteinases (gingipains) and hemagglutinins from the periodontal pathogen Porphyromonas gingivalis

Heme binding and uptake are considered fundamental to the growth and virulence of the gram-negative periodontal pathogen Porphyromonas gingivalis. We therefore examined the potential role of the dominant P. gingivalis cysteine proteinases (gingipains) in the acquisition of heme from the environment.

Saved in:
Bibliographic Details
Published in:Journal of bacteriology 1999-06, Vol.181 (12), p.3784
Main Authors: DeCarlo, Arthur A, Paramaesvaran, Mayuri, Yun, Peter L W, Collyer, Charles, Hunter, Neil
Format: Article
Language:English
Subjects:
Bacteria
Bacteriology
Enzymes
Hemoglobin
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Heme binding and uptake are considered fundamental to the growth and virulence of the gram-negative periodontal pathogen Porphyromonas gingivalis. We therefore examined the potential role of the dominant P. gingivalis cysteine proteinases (gingipains) in the acquisition of heme from the environment.
ISSN:0021-9193
1098-5530