Gastroprotective Effect of Lannea coromandelica Stem Bark in Rat induced by Aspirin

• Published in: Research journal of pharmacy and technology 2019-04, Vol.12 (4), p.1646-1648
• Main Authors: Pusmarani, Jastria, Ifaya, Mus, Isrul, Muhammad, Saleh, Ahmad, Himaniarwati
• Format: Article
• Language: English
• Subjects: Antioxidants; Aspirin; Drug dosages; Ethanol; Phytochemicals; Sterols; Studies; Ulcers; Weaning
• ISSN: 0974-3618; 0974-360X; 0974-306X
• DOI: 10.5958/0974-360X.2019.00275.0

Gastro protective Activity Assay: Stem Bark of Lannea coromandelica Dosage: Based on the research conducted by Santhi et al in 2015 stated that the dosage of leaves extract of Lannea coromandelica is 200 mg/kgBW and 400 mg/kgBW have antiulcer activity. [...]the dosage applied for the stem bark of Lannea coromandelica in this research is 400 mg/kg BW, 800 mg/kgBW and 1200 mg/KgBW Aspirin Induced Application: The dosage of aspirin known to damage gastric mucosa of rat is 600 mg/kgBW (Sangelorang, 1998). On the fourth day, 4 hours after aspirin injection all tested animals are slaughtered to get their gastric and scored. [...]score given is as follows: 1 = if lesion < 1.00 mm; 2 = if lesion 1.00-2.00 mm; 3 = if lesion 2.01-3.00 mm; 4 = if lesion 3.01-4.00 mm; 5 = if lesion 4.01-5.00 mm; 10 = if lesion > 5.00 mm; 25 = if perforation occur7. Peptic ulcer is one of gastrointestinal disease that occurs because of the imbalance between mucosa protection factor (bicarbonate, mucin, prostaglandin, nitrogen monoxide (NO) and growth factor) as well as aggressive factor (acid and pepsin). [...]if the fibrin clots quickly formed, then fibroblast will immediately proliferate to the wound to heal the tissues10.