Estimation of Almotriptan malate in tablets by sensitive Visible Spectrophotometric method

A simple, sensitive indirect visible spectrophotometric method has been developed for the estimation of almotriptan malate either in bulk or tablet dosage forms. The method is based on the oxidation of drug with excess N-Bromo succinimide and determining the unreacted NBS with reagents PMAP-SA by sp...

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Bibliographic Details
Published in:Research Journal of Science and Technology 2019, Vol.11 (1), p.77-81
Main Authors: Ramu, B. Kalyana, Bab, M. Syam, Prasad, U. Viplava, Babu, P. Konda
Format: Article
Language:English
Subjects:
Additives
Drug dosages
Formulations
Malate
Methods
Migraine
Oxidation
Pharmaceuticals
Quality control
Reagents
Spectrophotometry
Succinimide
Tablets
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Summary:A simple, sensitive indirect visible spectrophotometric method has been developed for the estimation of almotriptan malate either in bulk or tablet dosage forms. The method is based on the oxidation of drug with excess N-Bromo succinimide and determining the unreacted NBS with reagents PMAP-SA by spectrophotometrically at 520nm Beer's law obeyed in the concentration range of 4-20 pg/ml. No interference was observed from the usually existing additives in pharmaceutical formulations and the applicability of the method was examined by analyzing AXERT tablets containing AM. The statistical data indicates the accuracy, reproducibility and the precision of the proposed method.
ISSN:0975-4393
2349-2988
DOI:10.5958/2349-2988.2019.00012.3